Synthesis, anticoagulant and PIVKA-II induced by new 4-hydroxycoumarin derivatives

Drug likeness prediction of 5-hydroxy-substituted coumarins with high affinity to 5-HT1A and 5-HT2A receptors

“…The potency of coumarins may be modified by the number of small substituents, such as the hydroxy, alkoxy or carbonyl groups in various positions of coumarin moiety (Abdelhafez et al, 2010;Drzewiecka et al, 2013;Hassan et al, 2016;Paul et al, 2013;Sarkanj et al, 2013;Tsay et al, 2013). One of the latest trends is search for the new anti-psychotic drugs among coumarin derivatives, and their affinities to serotoninergic receptors 5-HT 1A and 5-HT 2A were defined (Chen et al, 2014;Chen et al, 2013).…”

Recent advances in 4-hydroxycoumarin chemistry. Part 1: Synthesis and reactions

“…These derivatives have shown a remarkably broad spectrum of pharmacological and physiological activities and they are used as anticoagulant (Abdelhafez et al, 2010;Au and Rettie, 2008;Ganguly et al, 2013;Guo et al, 2013;Palareti and Legnani, 1996;Pelz et al, 2005;Simon and Shaughnessy, 2004;Van Walraven et al, 2002), antibacterial (Brahmbhatt et al, 2013;Cespedes et al, 2006;El-Dean et al, 2013;Kidwai et al, 2014;Kumari et al, 2013;Musthaf et al, 2013;Pansuriya and Patel, 2007;Prasad et al, 2014), antifungal (Chohan et al, 2006;Rehman et al, 2005), antiviral (Kirkiacharian et al, 2008;Zavrsnik et al, 2011), antitumor (Arya et al, 2014;Bi et al, 2013;Dorababu et al, 2013;Farghaly et al, 2014;Kawaii et al, 2001;Kumar et al, 2013;Pingaew et al, 2014;Salinas-Jazmin et al, 2010;Loa et al, 2009), anticonvulsant (Jaweed Mukarram et al, 2005), antiprotozoal (Tasdmir et al, 2006), insecticidal , fungicide (Oliva et al, 2003), antimycobacterial (Abou-Melha and Faruk, 2008;Kotharkar and Shinde, 2006;Mostafa, 2008;Sukdolak et al, 2005;Zavrsnik et al, 2008), antimutagenic …”

Complexation, Spectroscopic, Thermal, Magnetic And Conductimetric Studies On Some 8-(Arylazo)Coumarins With Divalent Transition Metal Ions

“…Twenty 3-pyridinyl, pyrimidinyl and pyrazolyl-4-hydroxycoumarin derivatives were synthesized. The most prospective compounds were the 3-pyrazolyl-4-hydroxy coumarin derivatives [5]. The cyclo addition reaction of unsymmetrically N-substituted and Nunsubstituted 1,3-oxazolium-5-olates with selected 3-substituted coumarins has been examined [6].…”

“…Structural study of supramolecular photochemical β-cyclodextrin (β-CD)-coumarin derivatives systems and the crystal structure of the β-CD-4,7-dimethylcoumarin complex has been determined [9]. Two new coumarin derivatives, 7-(diethylamino)-3-(pyridin-2-yl)coumarin (DAPC) and 3-(pyridin-2-yl)-benzo [5,6]coumarin (PBC) were synthesized [10]. A novel ligand, 7-(2,3-dicyanophenoxy)-3-(2-chloro-4-fluorophenyl)coumarin was synthesized by the reaction of 3-(2-chloro-4-fluorophenyl)-7-hydroxycoumarin with 1,2-dicyano-3-nitrobenzen in dry DMF as the solvent in the presence of K 2 CO 3 as the base.…”