Synthesis, anticancer activity and mechanism of action of new phthalimido-1,3-thiazole derivatives

Discovery of novel thiazole derivatives as anti‐breast cancer agents (MCF‐7) and validation of homologous effects on SARS‐CoV‐2 virus using in silico approaches

“…The second data set is used for external validation of the models that have been created. All the references [6][7][8][9][10][11][12][13][14] can be found for the external test dataset in table 1 and the supplementary file. Therefore, in these sections 3.1 and 3.2, we can discuss how to build the QSARMLR and QSARANN models.…”

Copper supported modified magnetic carrageenan as a bio-based catalyst for the synthesis of novel scaffolds bearing the 1,2,3-triazole unit through the click reaction

“…There are several reports on the hybridization of triazoles with different cores such as phthalimides. 33–35 Phthalimides, the pharmaceutically active compounds, are also known for their potent biological activities, 36 such as anti-HIV, 37 anticancer, 38 anti-inflammatory, 39 hypoglycemic, 33 antimalarial, 40 histone deacetylase inhibitory, 41 cholinesterase inhibitory, 42 and COX inhibitory. 43 These compounds are also used as starting substances for the synthesis of a wide range of compounds, such as alkaloids, polymers, pesticides, and copolymers.…”

Phthalimides: developments in synthesis and functionalization

“…Phthalimides (isoindole-1,3-diones) are a well-known class of organic molecules, which are found in pharmaceuticals and natural products. [1][2][3][4][5] They display abundant biological potentials, such as anticancer, [6][7][8] antibacterial, 9,10 anti-inammatory, 11,12 antimalarial, 13,14 antifungal, 15 anxiolytic, 16 anti-HIV 17 and anticonvulsant 18,19 activities. Some phthalimide derivatives are in the drug market to treat psoriasis (apremilast), 20 myeloma (lenalidomide), 21 rheumatoid arthritis, 22 and shock septic syndrome (LASSBio-468).…”