Synthesis, antibacterial, antifungal activity and interaction of CT-DNA with a new benzimidazole derived Cu(II) complex

Synthesis and Biological Evaluation of Novel Benzimidazole Derivatives Bearing a Heterocyclic Ring at 4/5 Position

“…Starting from 2,3/3,4-diaminobenzoic acid (2), the synthetic route of the 2-substituent-1H-benzimidazole-4-carboxylic acids (6)(7)(8)(9)(10)(11)(12)(13)(14)(15) is shown in Scheme 1. 2-Substituent-1H-benzimidazole-4-carboxylic acids (6-13) were obtained by condensation of 2,3/3,4-diaminobenzoic acid (2) with aryl and heteroaryl aldehydes in the presence of 1,4-benzoquinone.…”

“…1,2,4-Oxadiazoles (21)(22)(23)(24)(25)(26)(27)(28)(29)(30) were obtained by the treatment of compounds (6)(7)(8)(9)(10)(11)(12)(13)(14)(15) with N-hydroxyacetamidine under EDC/ HOBT conditions. The acid hydrazides (18) was treated with acetic acid in the presence of phosphorus oxychloride afforded 1,3,4-oxadiazoles (31-32).…”

In Vitro Biological Screening for Antimicrobial, DNA Cleavage Anti-Diabetic, Antioxidant, Anti-Inflammatory and Antihaemolytic of Some Metallocephalosporins

“…Furthermore, the metal complexes form a hydrogen bond with the active centres of organism'scell constituents resulting in the perturbation of the normal cell respiratory process of the microbe. Thus, the complexation enhances the penetration and hence the rate of uptake/entrance of the metal into microbial cell and thus able to kill it [47].…”

“…The variation in the activity of different complexes against different organisms depends either on the impermeability of the cells of the microbes or on differences in ribosome of microbial cells. The increasing in the activity of the complexes was due to the coordination of metal ion to the antibiotic enhance the lipophilic character of the central metal atom [47][48][49].Generally, metal complexes are more active than the ligands because metal complexes may serve as a vehicle for activation of ligands as the principal cyctotoxic species.…”

Biological activity of bis-benzimidazole derivatives on DNA topoisomerase I and HeLa, MCF7 and A431 cells

“…The diverse substitutions of benzimidazole compounds give rise to antihelmintic [1,2], antifungal [3 -5], antitumor [6], antiviral [3,4], H 2 receptor blocker and proton pump inhibitor activities [7]. Several benzimidazole derivatives are also active as inhibitors of DNA topoisomerases [8 -11].…”