Synthesis, antibacterial, and antioxidant activity of [3-(4-chlorophenyl)-3-(4-fluorophenyl)propyl]- substituted ammonium oxalates

Cu-Catalyzed Remote Transarylation of Amines via Unstrained C–C Functionalization

“…Next, the analogue of drug molecules, Clofibrate and Beclobrate, were obtained via this Cu-catalyzed unstrained C–C utilization reaction ( 7c and 7d ) in moderate yields (Figure b). Moreover, bioactive molecule 7e , which shows potential antibacterial activity, was obtained employing this strategy in two steps from corresponding N–F precursor in 29% overall yield (Figure c) . This aryl exchange protocol provides an opportunity for late-stage diversification of the scaffold to easily access the analogue library compared to traditional linear synthesis procedures.…”

Synthesis of 3-(4-isopropoxyphenyl)-4-methylpentanoic acid amides

“…Amides are of particular interest due to the application in synthesis of different classes of compounds with wide range of biological activity [1][2][3][4].…”