Synthesis, Antibacterial and Antifungal Activity of 5-Aryl Amido-6-Isopropyl-2-(Mercapto/Hydroxy)-4-[(4′-Difluoro Methoxy) (3′-Hydroxy) Phenyl]-1,4-Dihydro Pyrimidine

Abstract

Various isopropylacetoacetanilides were treated with 4-(difluoromethoxy)-3-hydroxy benzaldehyde and thiourea/urea in the presence of acid catalyst to produce the 1,4-dihydropyrimidine derivatives (4a-5i and 5a-5i) with good yields. All the synthesized compounds were characterized by mass, 1H-NMR and IR spectrum, also evaluated for antibacterial and antifungal activity against two Gram +ve and two Gram-ve bacterial and fungi strains. The compounds 4e, 4g and 5d were found comparatively promising active against all the bacterial and fungal strains.