Synthesis, anti-inflammatory evaluation and docking studies of some new fluorinated fused quinazolines

Recent Advances of Quinazolinone Derivatives as Marker for Various Biological Activities

“…Among six-membered heterocycles, quinazoline occupies significant position and is commonly found in a wide variety of natural products, synthetic pharmaceutical molecules, and other functional materials 5 .The critical role played by heterocycles in drug design cannot be denied. Even where the natural substrate or ligand for a biological target does not contain a heterocycle, drugs whether of natural or man-made origin that act on that target frequently contain heterocyclic groups 6 . The aim of this review is to highlight the wide range of developments displayed by Quinazolinone Derivatives which have been found to possess wide spectrum of activities such as anti-inflammatory, antioxidant, antimicrobial, antipsychotic, antihypertensive [7][8][9][10][11] .…”

2-Aryl-6,8-dibromo-2,3-dihydroquinazolin-4(1<i>H</i>)-ones as substrates for the synthesis of 2,6,8-triarylquinazolin-4-ones

“…as coupling partners to afford the cross-coupled products 4a-h in appreciable yields and high purity without the need for column chromatography (Scheme 3). The heterocyclic ring of the 2,3-dihydroquinazolin-4(1H)-ones has been found to undergo a different degree of unsaturation through dehydrogenation or aromatization to afford the potentially tautomeric quinazolin-4(3H)-ones or their quinazoline derivatives [28][29][30][31][32]. Quinazolin-4(3H)-ones are versatile building blocks in the synthesis of novel 2,3-disubstituted quinazolinones [28][29][30][31] and their 2,4-disubstituted quinazoline derivatives using the principles of lactam-lactim dynamic equilibrium phenomena [32].…”

“…The heterocyclic ring of the 2,3-dihydroquinazolin-4(1H)-ones has been found to undergo a different degree of unsaturation through dehydrogenation or aromatization to afford the potentially tautomeric quinazolin-4(3H)-ones or their quinazoline derivatives [28][29][30][31][32]. Quinazolin-4(3H)-ones are versatile building blocks in the synthesis of novel 2,3-disubstituted quinazolinones [28][29][30][31] and their 2,4-disubstituted quinazoline derivatives using the principles of lactam-lactim dynamic equilibrium phenomena [32]. Oxidants such as KMnO 4 [28], CuCl 2 [29], DDQ [30] and MnO 2 [31] have been employed before in stoichiometric or large excess to convert the 2,3-dihydroquinazolin-4(1H)-ones into their quinazolin-4(3H)-one derivatives.…”

Synthesis and Photophysical Property Studies of the 2,6,8-Triaryl-4-(phenylethynyl)quinazolines

“…The potentially tautomeric quinazolin-4(3H)-one moiety itself is readily accessible via dehydrogenation of the corresponding 2,3-dihydroquinazolin-4(1H)-one precursors using oxidants such as KMnO 4 [10], CuCl 2 [11], DDQ [12] and MnO 2 [13] in stoichiometric or large access. The 2-substituted quinazolin-4(3H)-ones have also been synthesized directly from anthranilamide and aldehydes using NaHSO 3 [14], DDQ [15], CuCl 2 (3 equiv.)…”