Synthesis, anti-inflammatory, and antiproliferative activity evaluation of isoindole, pyrrolopyrazine, benzimidazoisoindole, and benzimidazopyrrolopyrazine derivatives

Abstract

A number of isoindole (3x, 3y, 6xa-6ye), pyrrolopyrazine (3z, 6za-6ze), benzimidazoisoindole (4x, 4y, 7xa-7ye), and benzimidazopyrrolopyrazine (4z, 7za-7ze) derivatives has been synthesized in excellent yields. All these compounds were fully characterized and evaluated against five human cancer cell lines for their anti-inflammatory and antiproliferative activity. Compounds 6yc and 7zd exhibited good anti-inflammatory activity whereas compounds 6zc, 7zd (lung NCl H-522), 6ye, 7xd, 7yd, 7zc, 7zd (colon HCT-15), 6xc, 7zc (ovary PA-1), 6xc, 6yb, 6zc (liver HepG-2) exhibited good antiproliferative activity.

Microwave-Induced Synthesis of Heterocycles of Medicinal Interests

“…Later, the same research group carried out microwave-induced synthesis of isoindole, pyrrolopyrazine, benzimidazoisoindole, and benzimidazopyrrolopyrazine derivatives [57] following the previously reported procedure. Two of these compounds (derivatives of 37) demonstrated anti-inflammatory activity, comparable to standard drug ibuprofen.…”

Substrate-controlled Rh(iii)-catalyzed regiodivergent annulation towards fused and spiro benzimidazoles

“…2 Benzimidazoisoindole (III) is antiproliferative to the colon HCT-15 cell line. 3 Isoindolo [2,1-a]benzimidazole-11-one (IV) as a disperse dye shows good fastness properties. 4 Over the past few decades, transition metal-catalyzed cascade cyclization has emerged as an attractive and powerful strategy for the construction of hybrid molecules using various combinations of pharmacophores and natural product motifs.…”

Whole-genome sequence of bioactive streptomycete derived from mangrove forest in Malaysia, Streptomyces sp. MUSC 14

“…MUSC 14 was isolated from the mangrove forest on the west coast of Peninsular Malaysia during a screening program for bioactive actinobacteria [4,51,52] . A thorough investigation conducted on the strain has reflected the antioxidant potential of MUSC 14, attributed to its production of bioactive secondary metabolites, including pyrrolopyrazines and fatty acid esters [51,[53][54][55] . The current study aims to obtain the genome sequence of Streptomyces sp.…”