Synthesis, anti-inflammatory activity of picen-13-ylmethylene derivatives

Abstract

A series of picene-13-ylmethylene derivatives (11-17) were synthesized by Knoevenagel condensation of active methylene compounds with picene-13-carbaldehyde.

Synthesis, spectroscopic characterization, quantum chemical calculations, evaluation of biological and cytotoxic activities, and molecular docking studies of 2‐hydroxy‐N′‐(4,5,6‐trimethoxy‐2,3‐dihydro‐1H‐inden‐1‐ylidene) benzohydrazide and its Cu(II), Co(II), Ni(II), and Zn(II) complexes

“…4,5,6‐trimethoxy‐1‐indanone is a ubiquitous indenone moiety in a variety of therapeutic agents with a broad spectrum of pharmacological activities including antibacterial antioxidant, and antihyperglycemic . The 5,6‐dimethoxy‐1‐indanone moiety coupled with various heterocyclic derivatives led to an enthralling array of application programming interfaces, which has potent antimycobacterial, antitubercular, anticonvulsant, anti‐inflammatory and antiproliferative activities . 4,5,6‐trimethoxy‐1‐indanone play a vital role in discovering new analogs of acetyl cholinesteras and β‐secretase 1 inhibitors and also used in the construction of perylenequinone cores .…”