Synthesis and X-ray structure of platinum(II), palladium(II) and copper(II) complexes with pyridine–pyrazole ligands: Influence of ligands’ structure on cytotoxic activity

Tautomeric forms study of 1H-(2′-pyridyl)-3-methyl-5-hydroxypyrazole and 1H-(2′-pyridyl)-3-phenyl-5-hydroxypyrazole. Synthesis, structure, and cytotoxic activity of their complexes with palladium(II) ions

“…The phenyl substituent at atom C8 is bent out from this molecular plane by only 43.8(3)°. The relevant dihedral angle is smaller than in the similar Pt-complex with a phenolic substituent (~70°) 52 , because of less steric hindrance. In the structure, an intermolecular hydrogen bond between compound 4 and the disordered methanol molecule can be observed.…”

Spectroscopic, structure and DFT studies of palladium(II) complexes with pyridine-type ligands

“…Palladium complexes with aromatic N-containing ligands, e.g., derivatives of pyridine, quinoline, pyrazole, and 1,10-phenanthroline, have shown very promising antitumor characteristics [1][2][3][4]. Some of these complexes, especially the trans analogs with nonplanar heterocyclic amine ligands, have been found to overcome multifactorial cisplatin resistance in human ovarian cell lines [5,6].…”

Platinum(II) and palladium(II) complexes with (N,N′) and (C,N,N′)− ligands derived from pyrazole as anticancer and antimalarial agents: Synthesis, characterization and in vitro activities

“…In addition, it is well-known that azoles are valuable reagents in coordination chemistry and that their binding to a transition metal ion affects their properties and activities. Few complexes with pyrazole ligands showing an antitumor activity similar to that of cisplatin have been reported [11][12][13][14][15][16][17][18][19][20], but the effect produced by the substituents on the heterocycle has not been clarified so far. Within this therapeutic context, and in order to clarify this point and to elucidate the influence of mode of binding of this family of ligands in the biological activity of the complexes, we decided to synthesize the new pyrazole derivatives 1a-1c ( Fig.…”