Synthesis and X-ray Diffraction Study of thiosemicarbazone Palladacycles with dppm

Abstract

Cyclometallated compounds have been extensively studied, in particular those with palladium and platinum. This is because of their possible applications in medicinal chemistry, as anticancer or antimicrobial agents; in some cases, with similar results as cisplatin, carboplatin or oxaliplatin. What is also remarkable is their use as homogeneous catalysts, for example, in cross coupling reactions such as Suzuki–Miyaura or Mizoroki–Heck. Herein, we report the synthesis of different thiosemicarbazone ligands, which will be reacted with a palladium or platinum salt, to give the corresponding cyclometallated compounds; in addition, their reactivity with bis(diphenylphosphino)methane (dppm) will be studied. Characterization has been carried out by elemental analysis, IR spectroscopy, 1H and 31P NMR spectroscopy. Additionally, 1c has been studied by X-ray diffraction.

Palladium Cyclometallated Compounds: Evaluation of Their Catalytic Activity in Cross-Coupling Reactions

“…The reactions to obtain the thiosemicarbazone ligands, tetranuclear compounds with palladium and reaction of these compounds with dppm were carried out following the procedure we reported earlier [17].…”