Synthesis and Use of Poly (Ortho Esters) for the Controlled Delivery of Therapeutic Agents

Heller, Jorge

doi:10.1177/088391158800300201

Cited by 19 publications

(1 citation statement)

References 7 publications

(10 reference statements)

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“…1 Copolymers and homopolymers of glycolide and lactide have been widely used as the biodegradable scaffolds, due primarily to their proven safety profile and commercial availability. As requirements for physicochemical properties to suit different biomedical applications broaden, alternative biodegradable polymers, amongst which include the poly(anhydride)s, 2 poly(ortho-ester)s, 3 and poly(phosphoester)s 4 have been investigated. The widening scope of tissue engineering has spurred the interest in developing new biodegradable polymers.…”

Section: Introductionmentioning

confidence: 99%

Poly(phosphoester) ionomers as tissue‐engineering scaffolds

Wan

Mao²,

Wang

et al. 2004

J Biomed Mater Res

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Regenerative medicine requires scaffolds of divergent physicochemical properties for different tissue-engineering applications. To this end, a series of biodegradable poly(phosphoester) ionomers of the general composition [p(BHET-EOP-HOP/TC)] was synthesized, with BHET(bis-hydroxyl ethylene phosphate):EOP(ethylene phosphate):HOP(free phosphate) ratios of 60:20:20, 70:10:20, and 75:5:20, respectively. The 60/20/20 ionomer possessed the best tensile properties, exhibiting an average tensile modulus of 68 MPa and strain at break of 31%. Calcium treatment of the ionomer films led to significantly higher hardness and elastic moduli as measured by indentation. Calcium binding was evident from the increase in glass transition and melting temperatures, and a shift in the P-->O absorption in the FTIR spectrum. Stable N-hydroxysuccinimide ester (NHS) of the ionomers could be synthesized to facilitate derivatization, as demonstrated by conjugation of GRGDS in this study. The polymers conjugated with NHS were hydrolyzed in a biphasic mode, with a fast initial phase occurring in the first few hours, followed by a slower phase in the next few days. These ionomers represent a novel class of biomaterials with readily controllable physical and chemical attributes for tissue engineering.

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Section: Introductionmentioning

confidence: 99%