Synthesis and use of new fluorogenic precipitating substrates

Synthesis and Photophysical Property Studies of the 2,6,8-Triaryl-4-(phenylethynyl)quinazolines

“…The potentially tautomeric quinazolin-4(3H)-one moiety itself is readily accessible via dehydrogenation of the corresponding 2,3-dihydroquinazolin-4(1H)-one precursors using oxidants such as KMnO 4 [10], CuCl 2 [11], DDQ [12] and MnO 2 [13] in stoichiometric or large access. The 2-substituted quinazolin-4(3H)-ones have also been synthesized directly from anthranilamide and aldehydes using NaHSO 3 [14], DDQ [15], CuCl 2 (3 equiv.) [16], FeCl 3 .6H 2 O [17] or I 2 [18].…”

Application of Fluorescence Spectroscopy for Determining the Structure and Function of Proteins

“…These compounds can also act as substrates for the ubiquitous glutathione S-transferase system, which conjugates them in vivo to the tripeptide glutathione (GSH). Finally, several new substrates prepared from the 2'-hydroxyphenyl-4-(3H)quinoxazolinones ("ELF") precipitating fluorophores have also shown utility in labeling for [3-galactosidase in vivo (Naleway et al, 1994). Since the product of these substrates is difficult to quantitate, their use has been limited to qualitative analyses at present.…”

Zn[(L)-proline] as a Recyclable and Green Catalyst for Efficient and One-pot Three-Component Synthesis of 1,4-Dihydro- pyridines Under Solvent-Free and Microwave Irradiation Conditions

“…Other synthetic methods includes treatment of phosphoranes with NaH/CH 3 CN 20 , pyrolysis of Schiff bases derived from 3-amino-1,2,3-triazineone in paraffin oil at 300 0 C 21 . The most general method for synthesis of these compounds involves cyclocondensation of anthranilamides with aldehydes in the presence of various promoting agents, such as p-toluenesulfonic acid/DDQ 22 , I 2 /KI in water 23 , CuCl 2 in ethanol 24 , DDQ/DMF 25 , Sc(oTf) 3 26 , NaHSO 3 27 , SnCl 4 In continuation of our interest in finding environmentally benign method for the synthesis of various heterocyclic compounds [37][38][39][40][41][42] , here in we want to report for first time, a new and efficient synthesis of 4(3H)-quinazolinones in the presence ofZn[(L)-proline] 2 as a lewis acid catalyst under solvent-free conditions (Scheme 1).…”