Synthesis and thermotropic properties of novel double-chained quaternary ammonium chlorides with symmetric and asymmetric hydrocarbon chain length

Ding, Zhaoyun; Hao, Aiyou

doi:10.1016/j.molstruc.2009.02.013

Cited by 4 publications

(1 citation statement)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This feature is not uncommon for alkylammonium hydrochloride salts. [26,27] During the melting point determination, the product decomposes to a dark brown material rather than melting and the values obtained (220-230°C) were not reproducible. In the DSC experiments, it was found that each polymorph exhibited a single endothermic transition at 256°C; however, this transition does not seem to be related to a melting endotherm since no other transitions were detected in the cooling and second heating runs for each sample.…”

Section: Characterization Of Polymorphsmentioning

confidence: 99%

Identification of polymorphism in ethylone hydrochloride: synthesis and characterization

Maheux

Alarcon

Copeland

et al. 2015

Drug Testing and Analysis

View full text Add to dashboard Cite

Ethylone, a synthetic cathinone with psychoactive properties, is a designer drug which has appeared on the recreational drug market in recent years. Since 2012, illicit shipments of ethylone hydrochloride have been intercepted with increasing frequency at the Canadian border. Analysis has revealed that ethylone hydrochloride exists as two distinct polymorphs. In addition, several minor impurities were detected in some seized exhibits. In this study, the two conformational polymorphs of ethylone hydrochloride have been synthesized and fully characterized by FTIR, FT‐Raman, powder XRD, GC‐MS, ESI‐MS/MS and NMR (13C CPMAS, 1H, 13C). The two polymorphs can be distinguished by vibrational spectroscopy, solid‐state nuclear magnetic resonance spectroscopy and X‐ray diffraction. The FTIR data are applied to the identification of both polymorphs of ethylone hydrochloride (mixed with methylone hydrochloride) in a laboratory submission labelled as 'Ocean Snow Ultra’. The data presented in this study will assist forensic scientists in the differentiation of the two ethylone hydrochloride polymorphs. This report, alongside our recent article on the single crystal X‐ray structure of a second polymorph of this synthetic cathinone, is the first to confirm polymorphism in ethylone hydrochloride. © 2015 Canada Border Services Agency. Drug Testing and Analysis published by John Wiley & Sons, Ltd. © 2015 Canada Border Services Agency. Drug Testing and Analysis published by John Wiley & Sons, Ltd.

show abstract

Section: Characterization Of Polymorphsmentioning

confidence: 99%