Synthesis and thermoresponsive behavior of double hydrophilic graft copolymer based on poly(2-methyl-2-oxazoline) and poly(2-ethyl-2-oxazoline)

Glaive, Aline-Sarah; Volet, Gisèle

doi:10.1016/j.eurpolymj.2022.111504

Cited by 6 publications

(18 citation statements)

References 63 publications

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“…Grafting PEtOx on the same POx backbone has led to double-hydrophilic graft copolymers, POx-g-PEtOx copolymers, which have been shown to selfassemble into swollen spherical nanostructures at room temperature due to the incompatibilities between the graft chains and the backbone. 49 Self-associations in the form of compound micelles have also been reported in the case of PEtOx grafted onto a hydrophilic polytyrosine backbone. 64 Heterograft copolymers bearing PLA and PEtOx dangling chains and based on a PMMA backbone have been reported by the group of Schubert.…”

Section: Self-assembly Study Of the Heterograftmentioning

confidence: 89%

“…PEtOx-C�CH was synthesized through the cationic ring-opening polymerization of 2-ethyl-2-oxazoline, following a previously reported procedure. 49 Two polymer samples were synthesized, with a yield 70−75%. Their characteristics are reported in Table S2.…”

Section: Synthesis Of Alkynyl-terminated Poly(2-ethyl-2-oxazoline) (P...mentioning

confidence: 99%

“…A detailed discussion of the characterization results of homopolymers was described by our group. 49 Two samples were synthesized with different number-average molar weights determined by 1 H NMR (400 MHz, DMSO): 3.5 × 10 3 and 7.4 × 10 3 g mol −1 (Table S2). The dispersities of these PEtOx samples determined by size exclusion chromatography in aqueous solution are from 1.2 to 1.3.…”

Section: Synthesis and Characterization Of Heterograftmentioning

confidence: 99%

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Amphiphilic Heterograft Copolymers Bearing Biocompatible/Biodegradable Grafts

Glaive,

Cœur,

Guigner

et al. 2024

Langmuir

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The amphiphilic heterograft copolymers bearing biocompatible/biodegradable grafts [poly(2-methyl-2-oxazoline-co-2-pentyl-2-oxazoline)-g-poly(d-l-lactic acid)/poly(2-ethyl-2-oxazoline)] were synthesized successfully by the combination of cationic ring-opening polymerization and click chemistry via the ⟨“grafting to”⟩ approach. The challenge of this synthesis was to graft together hydrophobic and hydrophilic chains on a hydrophilic platform based on PMeOx. The efficiency of grafting depends on the chemical nature of the grafts and of the length of the macromolecular chains. The self-assembly of these polymers in aqueous media was investigated by DLS, cryo-TEM, and SANS. The results demonstrated that different morphologies were obtained from nanospheres and vesicles to filaments depending on the hydrophilic weight ratio in the heterograft copolymer varying from 0.38 until 0.84. As poly(2-ethyl-2-oxazoline) is known to be thermoresponsive, the influence of temperature rise on the nanoassembly stability was studied in water and in a physiological medium. SANS and DLS measurements during a temperature ramp allowed to show that nanoassemblies start to self-assemble in “raspberry like” primary structures at 50 °C, and these structures grow and get denser as the temperature is increased further. These amphiphilic heterograft copolymers may include hydrophobic drugs and should find important applications for biomedical applications which require stealth properties.

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Section: Self-assembly Study Of the Heterograftmentioning

confidence: 89%

Section: Synthesis Of Alkynyl-terminated Poly(2-ethyl-2-oxazoline) (P...mentioning

confidence: 99%

Section: Synthesis and Characterization Of Heterograftmentioning

confidence: 99%

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Amphiphilic Heterograft Copolymers Bearing Biocompatible/Biodegradable Grafts

Glaive,

Cœur,

Guigner

et al. 2024

Langmuir

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“…[28][29][30] Due to the favourable low-fouling properties 31,32 and low immunogenicity of hydrophilic PAOx, [33][34][35] they possess high potential for use in the field of nanomedicines and numerous studies have already investigated their potential in this area. [36][37][38][39] PAOx with longer alkyl side chains (e.g., ethyl, n-propyl, or iso-propyl) 40,41 as well as other functional side chains such as methyl esters 42 or nitriles 43 exhibit LCST behavior. In addition, PAOx with ionisable groups have been reported to be responsive to both, pH and temperature.…”

Section: Introductionmentioning

confidence: 99%

“…36–39 PAOx with longer alkyl side chains ( e.g. , ethyl, n-propyl, or iso -propyl) 40,41 as well as other functional side chains such as methyl esters 42 or nitriles 43 exhibit LCST behavior. In addition, PAOx with ionisable groups have been reported to be responsive to both, pH and temperature.…”

Section: Introductionmentioning

confidence: 99%