Synthesis and tensioactive properties of PEO-b-polyphosphate copolymers

Abstract

Investigation of the micellization of degradable polyphosphoester based surfactants following a solvent-free process: the role of the pendent chain.

Thiol-ene Reaction: An Efficient Tool to Design Lipophilic Polyphosphoesters for Drug Delivery Systems

“…Indeed, this work pays attention to amphiphilic diblock copolymers made up of hydrophilic PEG and hydrophobic PPE blocks. These copolymers are prone to self-assemble into nanoparticles in water [ 22 , 23 ] which makes them very attractive for drug delivery applications. In a previous work, we demonstrated that increasing the length of the PPE substituent from ethyl to heptyl favorably impacts the size and stability of the nanoparticles [ 23 ].…”

Polyphosphoesters: New Trends in Synthesis and Drug Delivery Applications

“…In line with ROP of lactones that can be initiated from macroinitiator such as monomethoxypoly(ethylene oxide) (PEO) to prepare diblock copolymers such as PEO‐ b ‐PLA or PEO‐ b ‐PLGA, similar diblock copolymers, PEO‐ b ‐PPE, of well‐controlled composition can be obtained by organocatalyzed ROP in presence of the selected PEO macroinitiator …”

“…By this reaction, a range of cyclic phosphotriester having R′ = H and various R groups that include alkyl chains of various size (methyl to octyl) and unsaturated chains (allyl, butenyl, butynyl, acrylate) has been obtained in good purity enough to be polymerized by the ROP process. However, the purification of these monomers that are highly sensitive toward traces of water or other protic species that easily open the ring, remains a tedious step.…”

“…In contrast to PLLA or PCL polyesters, PPEs are amorphous materials characterized by a low glass transition temperature ( T g ) (e.g., T g of PBP is −50 °C and of PBYP −35 °C).…”

“…In line with ROP of lactones that can be initiated from macroinitiator such as monomethoxypoly(ethylene oxide) (PEO) to prepare diblock copolymers such as PEO-b-PLA or PEO-b-PLGA, similar diblock copolymers, PEO-b-PPE, of wellcontrolled composition can be obtained by organocatalyzed ROP in presence of the selected PEO macroinitiator. [10][11][12][13] Besides a better polymerization efficiency, the organocatalysts present over the organometallic ones, the additional advantage to provide metal-free PPE. These organic molecules are more easily extracted from the polymer than metallic residues that require heavy purification steps to fulfill the requirements of biomedical applications.…”