Synthesis and tautomerism of 2-(3,5-diaryl-1H-pyrazol-4-yl)-1-methyl-1H-benzimidazoles

Dzvinchuk, I. B.; Lozinskii, M. O.

doi:10.1007/s10593-011-0691-6

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Cited by 4 publications

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Novel Pyrazole and Indazole Derivatives: Synthesis and Evaluation of Their Anti‐Proliferative and Anti‐Angiogenic Activities

Tzanetou¹,

Liekens²,

Kasiotis³

et al. 2012

Archiv der Pharmazie

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The synthesis of several new pyrazole and indazole derivatives from acetophenone and tetralone substrates is reported. The bioactivities of the new compounds were evaluated through in vitro assays for endothelial cell proliferation and tube formation. Results herein indicate that the easily prepared compounds containing the indazole structural framework exhibit potent cytostatic properties against all cell lines tested, with compounds 13 and 14 being the most active displaying IC(50) values of 1.5 ± 0.4 µM and 5.6 ± 2.5 µM, respectively, against MCF-7 cells. In addition, the indazole derivative 16 was assessed as a competent inhibitor of endothelial tube formation at 30 µM.

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Novel Pyrazole and Indazole Derivatives: Synthesis and Evaluation of Their Anti‐Proliferative and Anti‐Angiogenic Activities

Tzanetou¹,

Liekens²,

Kasiotis³

et al. 2012

Archiv der Pharmazie

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show abstract

ChemInform Abstract: Synthesis and Tautomerism of 2‐(3,5‐Diaryl‐1H‐pyrazol‐4‐yl)‐1‐methyl‐1H‐benzimidazoles (III).

Dzvinchuk

Lozinskii

2011

ChemInform

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Pyrazoles

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2022

Comprehensive Heterocyclic Chemistry IV

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Synthesis and tautomerism of 2-(3,5-diaryl-1H-pyrazol-4-yl)-1-methyl-1H-benzimidazoles

Abstract: H NMR spectra indicate that these products display tautomerism. The more stable tautomers have structures containing electron-donor aryl substituents at C-5 and electron-withdrawing aryl substituents at C-3 of the pyrazole ring.

Cited by 4 publications

References 10 publications

Novel Pyrazole and Indazole Derivatives: Synthesis and Evaluation of Their Anti‐Proliferative and Anti‐Angiogenic Activities

Novel Pyrazole and Indazole Derivatives: Synthesis and Evaluation of Their Anti‐Proliferative and Anti‐Angiogenic Activities

ChemInform Abstract: Synthesis and Tautomerism of 2‐(3,5‐Diaryl‐1H‐pyrazol‐4‐yl)‐1‐methyl‐1H‐benzimidazoles (III).

Pyrazoles

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