Synthesis and surface properties of semi-interpenetrating fluorine-containing polyacrylate and epoxy resin networks

Cui, Xuejun; Gao, Yan; Zhong, Shuangling; Zheng, Zaihang; Cheng, Ye; Wang, Hongyan

doi:10.1007/s10965-012-9832-6

Cited by 12 publications

(2 citation statements)

References 28 publications

(28 reference statements)

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“…In Figure 2a, fluorosilanization of PMMA resulted in the appearance of two new peaks in the C1s spectrum at 290.69 and 293.05 eV which are associated with CF2 and CF3, respectively. [ 69,70 ] These peaks confirm the formation of FS layer with the linear formula of CF 3 (CF 2 ) 5 CH 2 CH 2 SiCl 3 as the precursor. The O1s spectrum of plain PMMA surface in Figure 2b can be deconvoluted into primarily two peaks of CO at ≈533.3 eV and CO at 532 eV.…”

Section: Resultsmentioning

confidence: 99%

Antibody Micropatterned Lubricant‐Infused Biosensors Enable Sub‐Picogram Immunofluorescence Detection of Interleukin 6 in Human Whole Plasma

Shakeri

Jarad

Terryberry³

et al. 2020

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Recent studies have shown a correlation between elevated interleukin 6 (IL-6) concentrations and the risk of respiratory failure in COVID-19 patients. Therefore, detection of IL-6 at low concentrations permits early diagnosis of worstcase outcome in viral respiratory infections. Here, a versatile biointerface is presented that eliminates nonspecific adhesion and thus enables immunofluorescence detection of IL-6 in whole human plasma or whole human blood during coagulation, down to a limit of detection of 0.5 pg mL −1. The sensitivity of the developed lubricant-infused biosensor for immunofluorescence assays in detecting low molecular weight proteins such as IL-6 is facilitated by i) producing a bioink in which the capture antibody is functionalized by an epoxy-based silane for covalent linkage to the fluorosilanized surface and ii) suppressing nonspecific adhesion by patterning the developed bioink into a lubricant-infused coating. The developed biosensor addresses one of the major challenges for biosensing in complex fluids, namely nonspecific adhesion, therefore paving the way for highly sensitive biosensing in complex fluids. where significantly elevated levels indicate aggressive tumor growth or viral load and poor prognosis in patients. [2,10] Additionally, IL-6 is an important anti-inflammatory cytokine that induces acute responses in chronic inflammatory pathologies. As such, there has been an increasing interest in the use of IL-6 as a biomarker for the diagnosis of early stages of viral infections, cancer, and chronic inflammation. [9-11] A practical IL-6 biosensor should provide a low limit of detection (LOD) (≤5 pg mL −1) and acceptable linear dynamic range (1-100 pg mL −1) in complex fluids, in addition to accuracy, facile operation, and amenable to mass production. [11,12] There are a large number of different IL-6 detection techniques that have been reported in the literature including electrochemical sensors, [13-22] surface plasmon resonance (SPR), [23-25] chemiluminescence immunoassay (CLIA), [26-29] and immunofluorescence assays (IFA), [30-33] Utilizing 0-and 1-D materials such as carbon nanotubes (CNTs), [14,16] nanoparticles and nanowires, [13,19] as well as porous nanoparticles, [15] optical fibers, [32] and microfluidic platforms, [28] have enabled higher sensitivity in IL-6 detection and to date, electrochemical methods have proven to be the most promising candidate for detection of IL-6 at very low concentrations (0.33 pg mL −1 in buffer) with a wide linear dynamic range. [22] While reported IL-6 biosensors have demonstrated satisfactory LODs in buffer or processed serum, their performance in human whole plasma declines significantly, leading to higher LOD's and/or false positive results. In electrochemical sensors, for example, the nonspecific attachment of biological entities in plasma or blood can interfere with the resistivity at the electrodes thereby deteriorating their sensitivity for detection of IL-6 at clinically relevant concentrations. [34] So far, the lowest theoretical LOD fo...

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Section: Resultsmentioning

confidence: 99%

Antibody Micropatterned Lubricant‐Infused Biosensors Enable Sub‐Picogram Immunofluorescence Detection of Interleukin 6 in Human Whole Plasma

Shakeri

Jarad

Terryberry³

et al. 2020

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“…The obtained interpenetrated polymer network (IPN) coatings exhibited lower water diffusion coefficients and significant improvement in anticorrosive properties against hygrothermal cycling. Besides siloxanes, fluorine-containing segments were also used to enhance coatings' hydrophobicity and barrier properties [9,10].…”

Section: Introductionmentioning

confidence: 99%

Effect of Surface Microstructures on Hydrophobicity and Barrier Property of Anticorrosive Coatings Prepared by Soft Lithography

Zhang

Chen

et al. 2014

Advances in Materials Science and Engineering

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Enhancing the hydrophobicity of organic coatings retards their interaction with water and often leads to better protectiveness over metal corrosion. In this study, a soft lithography method was used to prepare epoxy coatings which showed surface microstructures in high replication to sandpapers. The effect of microstructures on coating’s hydrophobicity and barrier property was investigated. Compared to flat coatings, the microstructured coatings showed much higher water contact angles, which further increased with finer sandpapers. Determined by electrochemical impedance spectroscopy (EIS), the flat coating exhibited a higher anticorrosive performance than the microstructured coatings. With the use of finer sandpaper, the groove size of the corresponding microstructured coating was reduced. And a lower anticorrosive performance was observed since more defects might be formed in a given area of coating during the imprinting process. As the groove size of the coatings was further decreased to 5.7 µm, the microstructures became too small for water to easily penetrate through. Therefore, trapped air acted as an additional barrier and contributed to an increased anticorrosive performance compared to other microstructured coatings.

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Synthesis and characterization of cationic fluorinated polyacrylate soap-free latexes with core-shell structure

Hao

et al. 2013

J Polym Res

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Synthesis and surface properties of semi-interpenetrating fluorine-containing polyacrylate and epoxy resin networks

Cited by 12 publications

References 28 publications

Antibody Micropatterned Lubricant‐Infused Biosensors Enable Sub‐Picogram Immunofluorescence Detection of Interleukin 6 in Human Whole Plasma

Antibody Micropatterned Lubricant‐Infused Biosensors Enable Sub‐Picogram Immunofluorescence Detection of Interleukin 6 in Human Whole Plasma

Effect of Surface Microstructures on Hydrophobicity and Barrier Property of Anticorrosive Coatings Prepared by Soft Lithography

Synthesis and characterization of cationic fluorinated polyacrylate soap-free latexes with core-shell structure

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