Synthesis and Study on Magnetic Resonance Imaging Performance of Gd(iii)-Dtpa-Bisbenzothiazol Hydrazide

Abstract

In this paper, 2-hydrazino-6-methoxy-1,3-benzothiazole was introduced into diethylenetriamine pentaacetic (DTPA) by acylation reaction. The corresponding non-ion Gd(III) complex holding promise of a single molecule magnetic resonance imaging (MRI) contrast agent was obtained by treating this ligand with GdCl 3 •6H 2 O. The efficacy of the contrast agent was assessed by measuring the longitudinal relaxivity (r 1), the r 1 of Gd(III)-DTPA-bisbenzothiazole hydrazide was up to 6.44 mM −1 •s −1 , which was 1.8 times higher than that of the analogous MRI contrast agent Gd(III)-DTPA(r 1 = 3.64 mM −1 •s −1) in commercial use. In addition, in vitro MR images on a 0.5 T magnetic field exhibited a remarkable enhancement of signal contrast for Gd(III)-DTPA-bisbenzothiazole hydrazide than Gd(III)-DTPA. These results demonstrate that this non-ion Gd(III) complex acts as a potentially MRI contrast agent.

Sintesis Senyawa Berbasis Gadolinium Menggunakan Gliseril Monooleat Sebagai Ligan Dan Potensinya Sebagai Contrast Agents

“…Ramalho et al 2016). Contrast agents seperti Gadolinium-Diethylenetriamine Penta-Acetic acid (Gd-DTPA) telah lama digunakan, namun hasilnya belum cukup memuaskan karena waktu relaksasi yang rendah sehingga diperlukan dosis yang lebih tinggi (Wan et al 2016). Oleh karena itu, perlu dikembangkan contrast agents yang menghasilkan kontras yang lebih baik dengan dosis yang relatif rendah.…”