Synthesis and Study of Structure Silver Nanoparticles by Polyethyleneglycol - Gum Arabic Polymers

Humbatova, S.F.; Tapdigov, Shamo Z.; Zeynalov, N.A.; Taghiyev, D. B.; Mammadova, Samira

doi:10.4028/www.scientific.net/jnanor.45.25

Cited by 8 publications

(5 citation statements)

References 36 publications

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“…The use of silver nanoparticles (Ag NPs) is a promising approach in the development of antimicrobial alternatives. Having enhanced optical, physical and chemical properties due to their large reactive and exposed surface area, Ag NPs exhibit bactericidal activity predominantly through Ag + ions release and generation of reactive oxygen species (ROS) that can disrupt cell membranes and interfere with DNA replication . The unique intrinsic property of Ag NPs themselves or in combination with biomaterials like collagen, keratin, and hyaluronic acid have shown effective wound healing and control of microbial growth at the wound site…”

Section: Introductionmentioning

confidence: 99%

Ultrafine Silver Nanoparticles Embedded in Cyclodextrin Metal‐Organic Frameworks with GRGDS Functionalization to Promote Antibacterial and Wound Healing Application

Shakya

Ren

et al. 2019

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The challenge of bacterial infection increases the risk of mortality and morbidity in acute and chronic wound healing. Silver nanoparticles (Ag NPs) are a promising new version of conventional antibacterial nanosystem to fight against the bacterial resistance in concern of the drug discovery void. However, there are several challenges in controlling the size and colloidal stability of Ag NPs, which readily aggregate or coalesce in both solid and aqueous state. In this study, a template‐guided synthesis of ultrafine Ag NPs of around 2 nm using water‐soluble and biocompatible γ‐cyclodextrin metal‐organic frameworks (CD‐MOFs) is reported. The CD‐MOF based synthetic strategy integrates AgNO3 reduction and Ag NPs immobilization in one pot achieving dual functions of reduced particle size and enhanced stability. Meanwhile, the synthesized Ag NPs are easily dispersible in aqueous media and exhibit effective bacterial inhibition. The surface modification of cross‐linked CD‐MOF particles with GRGDS peptide boosts the hemostatic effect that further enhances wound healing in synergy with the antibacterial effect. Hence, the strategy of ultrafine Ag NPs synthesis and immobilization in CD‐MOFs together with GRGDS modification holds promising potential for the rational design of effective wound healing devices.

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Section: Introductionmentioning

confidence: 99%

Ultrafine Silver Nanoparticles Embedded in Cyclodextrin Metal‐Organic Frameworks with GRGDS Functionalization to Promote Antibacterial and Wound Healing Application

Shakya

Ren

et al. 2019

Small

132

112

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“…Silver nanoparticles are a potential new version of traditional antibacterial nano-systems for combating bacterial resistance and filling the medication discovery gap. However, managing their size and colloidal stability, which readily cluster or coalesce in solid and aqueous states, presents many obstacles (Humbatova et al 2017;Le Ouay and Stellacci 2015). Shakya et al (2019) used the water-soluble and biocompatible cyclodextrin-based metal-organic framework in the template-guided synthesis of ultrafine silver nanoparticles.…”

Section: Food Applicationsmentioning

confidence: 99%

Synthesis and potential applications of cyclodextrin-based metal–organic frameworks: a review

et al. 2022

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Metal–organic frameworks are porous polymeric materials formed by linking metal ions with organic bridging ligands. Metal–organic frameworks are used as sensors, catalysts for organic transformations, biomass conversion, photovoltaics, electrochemical applications, gas storage and separation, and photocatalysis. Nonetheless, many actual metal–organic frameworks present limitations such as toxicity of preparation reagents and components, which make frameworks unusable for food and pharmaceutical applications. Here, we review the structure, synthesis and properties of cyclodextrin-based metal–organic frameworks that could be used in bioapplications. Synthetic methods include vapor diffusion, microwave-assisted, hydro/solvothermal, and ultrasound techniques. The vapor diffusion method can produce cyclodextrin-based metal–organic framework crystals with particle sizes ranging from 200 nm to 400 μm. Applications comprise food packaging, drug delivery, sensors, adsorbents, gas separation, and membranes. Cyclodextrin-based metal–organic frameworks showed loading efficacy of the bioactive compounds ranging from 3.29 to 97.80%.

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“…In recent years, the Nagiyev Institute of Catalysis and Inorganic Chemistry of ANAS carries out a lot of research work on the synthesis and investigation of polymer nanogels for immobilization and targeted delivery of biologically active substances and drugs [4][5][6][7][8][9][10][11][12][13]. Among these of particular importance is the work on the synthesis and application of polymer vectors to maintain the long-term biological activity of the thyroid hormone substitute levothyroxine in the organism.…”

Section: Introductionmentioning

confidence: 99%

Immobilization of Levothyroxine in Quaternized N,n-Dietyl N-Methyl Chitosan Hydrogel and Chemical Nature of the Interaction

Safaraliyeva¹,

Hummetov²,

Tapdiqov³

et al. 2022

AChJ

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Immobilization of a thyroid hormone substitute of L-thyroxine on chitosan-based smart hydrogel structure was performed to reduce the side effects of the required daily dose. The hydrogel was obtained by the Schiff reaction of chitosan with acetaldehyde and quaternization with methyl iodide then by ion exchange with NaCl salt. Finally, a hydrogel was obtained from the treatment of chitosan-based salt at -200C. The amount of levothyroxine immobilized by physical sorption on the hydrogel was determined by molecular electron spectroscopy on basis especially absorption peak at 227 nm. Results of IR- and UV-Vis spectroscopic analyses revealed that the interaction between levothyroxine and hydrogel occurs mainly due to hydrogen bonding and orientation forces of intermolecular interaction

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Synthesis and Study of Structure Silver Nanoparticles by Polyethyleneglycol - Gum Arabic Polymers

Cited by 8 publications

References 36 publications

Ultrafine Silver Nanoparticles Embedded in Cyclodextrin Metal‐Organic Frameworks with GRGDS Functionalization to Promote Antibacterial and Wound Healing Application

Ultrafine Silver Nanoparticles Embedded in Cyclodextrin Metal‐Organic Frameworks with GRGDS Functionalization to Promote Antibacterial and Wound Healing Application

Synthesis and potential applications of cyclodextrin-based metal–organic frameworks: a review

Immobilization of Levothyroxine in Quaternized N,n-Dietyl N-Methyl Chitosan Hydrogel and Chemical Nature of the Interaction

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