Synthesis and Study of Some Novel Benzimidazole Analogs as Potential Antiulcer Agents

Patil, Avinash; Ganguly, Swastika; Hundiwale, Jogendra C.; Tayade, Santosh

doi:10.7439/ijpc.v2i3.679

Cited by 9 publications

(8 citation statements)

References 5 publications

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“…Fur ther more, benzimidazole moiety is a crucial template in medicinal chemistry because of its wide variety of reported biological and pharmacological activities, some of which include anticancer 11 , antimicrobial 12 , antitumor 13 , antimalarial 14 ,anti-HIV 15 , anti-inflammatory 16 , antitubercular 17 , anthelmintic 18 , anticonvulsant 19 , antioxidant 20 , anti-ulcer 21 , anti-HBV 22 , among others. The pharmacological investigation showed that the antagonism of Ang II-induced pressure response by oral administration of a series of benzimidazole hybrid was obviously superior to that of clinical drug standard used.…”

Section: -9mentioning

confidence: 99%

Facile Synthesis, Characterization and Antimicrobial Activity of 2-Alkanamino Benzimidazole Derivatives

Ajani¹,

Aderohunmu²,

Olorunshola³

et al. 2016

Orient. J. Chem

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Benzimidazole derivatives are known to represent a class of medicinally important compounds which are extensively used in drug design and catalysis. A series of 2-substituted benzimidazole derivatives 10a-i was herein synthesized from the reaction of o-phenylenediamine with some amino acids using ameliorable pathway. The chemical structures of the synthesized compounds were confirmed by IR, UV, 1 H-NMR, 13 C-NMR, Mass spectral and analytical data. The compounds were investigated for their antimicrobial activity alongside gentamicin clinical standard. The results showed that this skeletal framework exhibited marked potency as antimicrobial agents. The most active compound was 1H-benzo[d]imidazol-2-yl)methanamine, 10a.

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Section: -9mentioning

confidence: 99%

Facile Synthesis, Characterization and Antimicrobial Activity of 2-Alkanamino Benzimidazole Derivatives

Ajani¹,

Aderohunmu²,

Olorunshola³

et al. 2016

Orient. J. Chem

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“…The 4-methoxy phenyl piperazine substituted benzimidazole derivative (183) appeared to be the most effective agent (Patil et al, 2012). Chang et al (Chang et al, 2012) (Rajesh et al, 2017).…”

Section: Antiulcer Activitymentioning

confidence: 99%

“…Moreover, some benzimidazole-piperazine conjugated analogues were assessed for their in vivo antiulcer property. The 4-methoxy phenyl piperazine substituted benzimidazole derivative (183) appeared to be the most effective agent ( Patil et al, 2012 ). Chang et al ( Chang et al, 2012 ) developed a series of 3,4,5-trimethoxybenzylbenzimidazole derivatives among which compound 184 (2-fluorophenyl-5-methyl-1-(3,4,5-trimethoxybenzyl) benzimidazole) emerged as the most potent inhibitor of Helicobacter pylori growth and pathogenesis of host cells.…”

Section: Biological Activitiesmentioning

confidence: 99%

A Comprehensive Account on Recent Progress in Pharmacological Activities of Benzimidazole Derivatives

et al. 2021

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Nowadays, nitrogenous heterocyclic molecules have attracted a great deal of interest among medicinal chemists. Among these potential heterocyclic drugs, benzimidazole scaffolds are considerably prevalent. Due to their isostructural pharmacophore of naturally occurring active biomolecules, benzimidazole derivatives have significant importance as chemotherapeutic agents in diverse clinical conditions. Researchers have synthesized plenty of benzimidazole derivatives in the last decades, amidst a large share of these compounds exerted excellent bioactivity against many ailments with outstanding bioavailability, safety, and stability profiles. In this comprehensive review, we have summarized the bioactivity of the benzimidazole derivatives reported in recent literature (2012–2021) with their available structure-activity relationship. Compounds bearing benzimidazole nucleus possess broad-spectrum pharmacological properties ranging from common antibacterial effects to the world’s most virulent diseases. Several promising therapeutic candidates are undergoing human trials, and some of these are going to be approved for clinical use. However, notable challenges, such as drug resistance, costly and tedious synthetic methods, little structural information of receptors, lack of advanced software, and so on, are still viable to be overcome for further research.

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“…Imidazole is a five-membered aromatic heterocycle that exhibits a number of biological applications, such as antibacterial [18], anticancer [19], antiepileptic [20], antitubercular [21] activities, etc. Benzimidazoles are privileged structures related to their roles in medicinal chemistry, e.g., they play their role in antibacterial [22], antidiabetic [23], antiviral [24], antiulcer [25] activities, etc. Drugs containing quinazoline, imidazole, and benzimidazole are given in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

Recent Approaches for the Synthesis of Imidazoquinazolines and Benzimidazoquinazolines

Rafiq,

Aslam,

Ahmad

et al. 2023

Recent Advances on Quinazoline

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Heterocyclic ring systems are gaining attention due to their pivotal role in drug design and medicinal chemistry. Quinazolines are nitrogen-containing heterocyclic pharmacophoric units found in abundance in natural and pharmaceutical products. Imidazoquinazolines and benzimidazoquinazolines are fused tricyclic and tetracyclic heterocyclic moieties, respectively. Different isomeric forms of imidazoquinazolines and benzimidazoquinazolines exhibited a plethora of biological applications such as antitumor, antimicrobial, antioxidant, anti-inflammatory, antitubercular, anticancer, antihypertensive, anticonvulsant, antiviral, antimalarial, antiapoptotic, anti-proliferative activities, etc. This chapter addressed the recent synthetic strategies for medicinally privileged scaffolds; imidazoquinazolines and benzimidazoquinazolines. The synthetic routes of various isomeric forms of above-mentioned heterocycles have also been discussed.

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Synthesis and Study of Some Novel Benzimidazole Analogs as Potential Antiulcer Agents

Cited by 9 publications

References 5 publications

Facile Synthesis, Characterization and Antimicrobial Activity of 2-Alkanamino Benzimidazole Derivatives

Facile Synthesis, Characterization and Antimicrobial Activity of 2-Alkanamino Benzimidazole Derivatives

A Comprehensive Account on Recent Progress in Pharmacological Activities of Benzimidazole Derivatives

Recent Approaches for the Synthesis of Imidazoquinazolines and Benzimidazoquinazolines

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