Synthesis and structure of the first ribbed-functionalized quinoxaline clathrochelate: design of cage complexes for efficient intercalation into DNA structure

Thionations Using a P4S10−Pyridine Complex in Solvents Such as Acetonitrile and Dimethyl Sulfone

“…Thionation of Gly-Gly as well as piperazine-2,5-dione both gave good yields of the expected dithionated product (Table , entries 1 and 2). To further characterize the rather insoluble product, it was acetylated in hot acetic anhydride, which yielded the tetraacetylated product 35 (Figure ), which readily gave nice NMR spectra. …”

Interaction of Dichloride Iron(II) Clathrochelate with Dimercaptomaleodinitrile: Synthesis of the Precursor Monoribbed-Functionalized Phthalocyaninoclathrochelates and the Unexpected Formation of a New Thiophene-Containing Heterocyclic System in the Ribbed Chelate Fragment of the Clathrochelate Framework

“…Despite the fact that the vic -dichloride iron(II) clathrochelate easily reacts with thiolate anions, ,– ,– in CH 3 CN/DMF, its nucleophilic substitution with the potassium salt of dimercaptomaleodinitrile under different conditions led to the target complex 2 only in low yield (∼15%). The formation of a mixture of byproducts with low chromatographic mobility was also observed.…”

“…In particular, a new approach to the synthesis of air-stable cobalt(I) complexes used a macrobicyclic hexachloride ligand with six strongly electron-withdrawing substituents in chelate π-conjugated α-dioximate fragments . Di- and triribbed-functionalized macrobicyclic iron and ruthenium(II) mono-, di-, tri-, tetra-, and hexa-substituted tris-dioximates have previously been obtained starting from their reactive tri- and hexachloride clathrochelate precursors. ,– Monoribbed-functionalized (i.e., containing one or two functionalizing substituents in one of the three dioximate fragments) iron(II) clathrochelates have also been synthesized starting from the corresponding mono- and dichloride precursors. – The synthesis of ribbed-functionalized clathrochelates with substituents, which are able to coordinate a metal ion to produce polynuclear complexes with interaction through the clathrochelate framework metal centers, is of particular interest . We have attempted to obtain a series of macrobicyclic monoribbed-functionalized iron(II) tris-dioximates with a ribbed vic -dinitrile fragment, in particular, in the present study, to synthesize complex 2 , as a precursor of the monoribbed-functionalized hybrid phthalocyaninoclathrochelates, under different reaction conditions.…”

New o-carboranyl-containing capping agents for d-metal tris-dioximates and first bis-C-carboranylboron-capped iron(II) clathrochelates: Synthesis and X-ray structure

“…These compounds have been used widely as a ''molecular scaffold" for the design of polytopic, polyfunctional and polynuclear systems [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. In particular, the ribbed-functionalized clatrochelates both with the inherent and with the terminal closo-borate substituents synthesized recently have been proposed as new radiopharmaceuticals for boron neutron capture therapy of cancer [12,17].…”