Synthesis and structure of platinum(II) complexes containing an asymmetric chelating diamine 2-morpholinoethylamine as the carrier

Chen, Xi-Zhu; Xie, Ming‐Jin; Liu, Weiping; Ye, Qingsong; Yu, Yanyan; Hou, Shuhua; Gao, Wengui; Yang, Liu

doi:10.1016/j.ica.2007.01.016

Cited by 15 publications

(13 citation statements)

References 12 publications

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“…The N1-Pt-N2 and O1-Pt1-N3 angles are 92.5(5)°and 91.6(5)°, respectively. All these agree well with the data of related platinum complexes described in the literature [12][13][14][15][16][17]. The C1-O1 and C1-O2 bond lengths are 1.250(17) and 1.294(18) Å , respectively, while the C2-O3 and C2-O4 bond lengths are 1.240(19) and 1.214(18 Å , respectively, consistent with a monodentate coordination mode for the carboxylates [18][19][20].…”

Section: Resultssupporting

confidence: 91%

An unexpected triammine(oxalato)platinum(II) complex obtained from the aqueous solution of tetraammineplatinum(II) oxalate

Chen

Xie

et al. 2011

Res Chem Intermed

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An unexpected complex, triammine(oxalato)platinum(II) in which oxalate anion acts as a monodentate ligand, was isolated in the process of recrystallizing [Pt(NH 3 ) 4 ](C 2 O 4 ). The complex was presumably formed via the loss of one ammonia molecule from [Pt(NH 3 ) 4 ](C 2 O 4 ), followed by the binding of oxalate from the outer coordination sphere. Single crystal X-ray diffraction study revealed that the Pt(II) atom was coordinated on a distorted square by three N atoms of the ammine molecules and one O atom of the oxalate ligand. The crystal packing was stabilized by moderate to strong hydrogen bonds formed between ammine, water molecules and O atoms of oxalate with d(NÁÁÁO) in the range of 2.84(2)-3.29(2) Å , and d(OÁÁÁO) in the range of 2.86(2)-3.37(2) Å . The complex underwent thermal decomposition at 200-231°C in the nitrogen atmosphere, giving rise to Pt, NH 3 and CO 2 .

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Section: Resultssupporting

confidence: 91%

An unexpected triammine(oxalato)platinum(II) complex obtained from the aqueous solution of tetraammineplatinum(II) oxalate

Chen

Xie

et al. 2011

Res Chem Intermed

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“…The cellular survival was evaluated by the MTT method [21,22]. Cells were plated onto 96-well sterile plates in 100 lL of medium at a density of 2610 3 cells per well and incubated for 48 h at 378C in a 7% CO 2 -containing incubator.…”

Section: In-vitro Cytotoxicity Assaysmentioning

confidence: 99%

Synthesis, Characterization and Cytotoxicity of Diam(m)‐ineplatinum(II) Complexes Containing β‐phenylisosuccinate Ligand

Ye¹,

Lou²,

Liu³

et al. 2007

Archiv der Pharmazie

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“…A549 is sensitive to cisplatin and carboplatin, whereas A549/ATCC is resistant to sev- eral anticancer drugs including cisplatin and carboplatin. HT-29 and LNcap are insensitive to carboplatin [25]. The dicarboxylate complexes 2-4 did not show any significant cytotoxicity in these cells.…”

Section: Resultsmentioning

confidence: 82%

Synthesis and Cytotoxicity of Platinum(II) Complexes of a Physiologically Active Carrier Histamine

Chen

Lou

et al. 2008

Archiv der Pharmazie

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A series of novel platinum(II) complexes involving a physiologically active carrier histamine as the carrier, cis-[Pt(histamine)X2] (X2=2Cl-, oxalate, malonate, 1,1-cyclobutanedicarboxylate (CBDCA), 3-hydroxy-1,1-cyclobutanedicarboxylate (HO-CBDCA)), have been synthesized and characterized by elemental analysis and spectroscopic data along with X-ray crystal structure for a representative complex cis-[Pt(histamine)Cl2]. The cytotoxicity of the complexes has also been assessed in the human cancer cell lines A549/ATCC, HT-29, and LNcap. One complex, cis-[Pt(histamine)Cl2], is more active than carboplatin against both the sensitive and resistant cells.

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Synthesis and structure of platinum(II) complexes containing an asymmetric chelating diamine 2-morpholinoethylamine as the carrier

Cited by 15 publications

References 12 publications

An unexpected triammine(oxalato)platinum(II) complex obtained from the aqueous solution of tetraammineplatinum(II) oxalate

An unexpected triammine(oxalato)platinum(II) complex obtained from the aqueous solution of tetraammineplatinum(II) oxalate

Synthesis, Characterization and Cytotoxicity of Diam(m)‐ineplatinum(II) Complexes Containing β‐phenylisosuccinate Ligand

Synthesis and Cytotoxicity of Platinum(II) Complexes of a Physiologically Active Carrier Histamine

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