Synthesis and structure of novel phosphonodipeptides containing a uracil or thymine group

Liu, Xuejun; Chen, Ruyu; Weng, Linhong; Leng, Xuebing

doi:10.1002/1098-1071(2000)11:6<422::aid-hc11>3.0.co;2-j

Cited by 11 publications

(4 citation statements)

References 21 publications

(20 reference statements)

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“…Tetraaminoporphyrin Zn(II) and thymin-1-ylacetic acid were synthesized as reported (Liu et al, 2000;Yuasa et al, 2004). All solvents were purchased from a commercial source and used without further purification unless otherwise noted.…”

Section: Reagents and Apparatusmentioning

confidence: 99%

A highly sensitive and reversible chemosensor for Hg²⁺ detection based on porphyrin‐thymine conjugates

Yang

Chen

et al. 2015

J of Molecular Recognition

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In this study, we demonstrated a highly sensitive, selective, and reversible chemosensor for Hg(2+) determination. This chemosensor was synthesized by direct condensation of thymin-1-ylacetic acid with zinc tetraaminoporphyrin, which has a porphyrin core as the fluorophore and four thymine (T) moieties as the specific interaction sites for Hg(2+) . The probe (4T-ZnP) exhibited split Soret bands with a small peak at 408 nm and a strong band at 429 nm in a dimethylformamide/H2 O (7/3, v/v) mixed solvent as well as a strong emission band at 614 nm. Upon the addition of Hg(2+) , the probe displayed strong fluorescence quenching due to the formation of T-Hg(2+) -T complexes. With the aid of the fluorescence spectrometer, the chemosensor in the dimethylformamide/H2 O (7/3, v/v) mixed solvent (0.3 μM) exhibited a detection limit of 6.7 nM. Interferences from other common cations, such as Co(2+) , K(+) , Sn(2+) , Zn(2+) , Cu(2+) , Ni(2+) , Mn(2+) , Na(+) , Ca(2+) , Mg(2+) , Pb(2+) , and Cd(2+) , associated with Hg(2+) analysis were effectively inhibited.

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Section: Reagents and Apparatusmentioning

confidence: 99%

A highly sensitive and reversible chemosensor for Hg²⁺ detection based on porphyrin‐thymine conjugates

Yang

Chen

et al. 2015

J of Molecular Recognition

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“…In order to utilize either uracil or cytosine as the base for the triazole-phosphoramidite, the respective N 1 -substituted acetic acids of the bases are synthesized. These precursors are synthesized based on methods from Leng and coworkers (Liu et al, 2000) and Nielsen…”

Section: Preparation Of Uracil and Cytosine Pyrimidine Basesmentioning

confidence: 99%

“…Preparation strategies for both carboxylic acid derivatives of the uracil (2) and cytosine (5) pyrimidine bases were adopted from already published protocols and proceed smoothly with high yield without the requirement of column chromatography (Christensen et al, 1998;Liu et al, 2000). The alkyne and azide linkers are synthesized from readily accessible starting materials.…”

Section: Synthesis Of the Triazole Phosphoramiditesmentioning

confidence: 99%

Synthesis of Triazole‐Nucleoside Phosphoramidites and Their Use in Solid‐Phase Oligonucleotide Synthesis

Peel

Efthymiou

Desaulniers

2013

CP Nucleic Acid Chemistry

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Triazole-backbone oligonucleotides are macromolecules that have one or more triazole units that are acting as a backbone mimic. Triazoles within the backbone have been used within oligonucleotides for a variety of applications. This unit describes the preparation and synthesis of two triazole-nucleoside phosphoramidites [uracil-triazole-uracil (UtU) and cytosine-triazole-uracil (CtU)] based on a PNA-like scaffold, and their incorporation within oligonucleotides.

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“…On the other hand, many heterocyclic phosphonates have been proven to be biologically active [32][33][34]. In continuation of our study on the synthesis of heterocyclic phosphonate derivatives [36,37] with bioactivities, we report a new convenient way to synthesize 1-hydroxyphosphonates from heterocyclic aldehydes and ketones, on the solid support of MgO, using MW irradiation.…”

Section: Introductionmentioning

confidence: 99%

A new convenient way to synthesize 1‐hydroxyphosphonates from heterocyclic aldehydes and ketones under microwave irradiation

Feng

Chen

Huang

et al. 2007

Heteroatom Chemistry

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Synthesis and structure of novel phosphonodipeptides containing a uracil or thymine group

Cited by 11 publications

References 21 publications

A highly sensitive and reversible chemosensor for Hg²⁺ detection based on porphyrin‐thymine conjugates

A highly sensitive and reversible chemosensor for Hg²⁺ detection based on porphyrin‐thymine conjugates

Synthesis of Triazole‐Nucleoside Phosphoramidites and Their Use in Solid‐Phase Oligonucleotide Synthesis

A new convenient way to synthesize 1‐hydroxyphosphonates from heterocyclic aldehydes and ketones under microwave irradiation

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Synthesis and structure of novel phosphonodipeptides containing a uracil or thymine group

Cited by 11 publications

References 21 publications

A highly sensitive and reversible chemosensor for Hg2+ detection based on porphyrin‐thymine conjugates

A highly sensitive and reversible chemosensor for Hg2+ detection based on porphyrin‐thymine conjugates

Synthesis of Triazole‐Nucleoside Phosphoramidites and Their Use in Solid‐Phase Oligonucleotide Synthesis

A new convenient way to synthesize 1‐hydroxyphosphonates from heterocyclic aldehydes and ketones under microwave irradiation

Contact Info

Product

Resources

About

A highly sensitive and reversible chemosensor for Hg²⁺ detection based on porphyrin‐thymine conjugates

A highly sensitive and reversible chemosensor for Hg²⁺ detection based on porphyrin‐thymine conjugates