Synthesis and structure of new derivatives of salicylic acid hydrazide

Нуркенов, О. А.; Фазылов, С. Д.; Сатпаева, Ж. Б.; Сейлханов, Т. М.; Karipova, G.Zh.; Isaeva, A. Zh.

doi:10.1134/s1070363214090369

Cited by 6 publications

(3 citation statements)

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“…1 Н NMR, δ, ppm (J, Hz): 7.45 t (1Н, Н 16 , 3 J 8.5), 7.78 d (3Н, Н 3,5,17 , 3 J 4.9), 8.05 d (1Н, Н 2,6 , 3 J 6.7), 8.39 s (1Н, Н 11 ), 8.75 d (2Н, Н 2,6 , 3 J 4.3), 12.20 s (1Н, Н 9 ). 13 N-(3-Fluorobenzylidene)isonicotinohydrazide (10). IR (KBr, v max /сm -1 ): 3237 (N-H), 1693 (C=O аmid ), 1605 (C=N).…”

Section: General Methods Of Obtaining Compounds 1-15mentioning

confidence: 99%

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Synthesis, Structure and Antiradical Activity of Functionally Substituted Hydrazides of Isonicotinic Acid

Nurkenov,

Fazylov,

Shulgau

et al. 2023

Eurasian Chem. Tech. J.

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The purpose of this work is the synthesis of new isonicotinic acid hydrazones, the study of their structure, reactivity and biological screening of some synthesized compounds. The reactions leading to new N-arylidene(alkylidene) hydrazones via the condensation of isonicotinic acid hydrazide with various derivatives of aromatic aldehydes were studied. The structure of the new functionally substituted isonicotinic acid hydrazones was established by FTIR, 1H and 13C NMR, two-dimensional COSY (1H-1H) NMR spectroscopy and HMQC (1H-13C). The antiradical activity of the synthesized derivatives was studied using diphenylpycrylhydrazide radical (DPPH) assay. It was shown that N-(3- ethoxy-4-hydroxybenzylidene)isonicotinohydrazide possesses antiradical activity (IC50 (DPPH) 103.0 μM). The antiradical properties of compounds of phenolic nature are in agreement with the energies of homolytic O-H bond dissociation calculated with the use of density functional theory.

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Section: General Methods Of Obtaining Compounds 1-15mentioning

confidence: 99%

“…Recently, there have been many reports that isoniazid and its derivatives used to prevent and treat tuberculosis are not free from side effects [10]. As pharmacological agents, they can cause changes in the metabolic and structural-functional state of the organs and systems of the living organism.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Structure and Antiradical Activity of Functionally Substituted Hydrazides of Isonicotinic Acid

Nurkenov,

Fazylov,

Shulgau

et al. 2023

Eurasian Chem. Tech. J.

View full text Add to dashboard Cite

show abstract

“…In addition to the activity against the Tubercule bacilli, their effect on other bacteria has also been studied. Some novel substituted 1, 3,4-oxadiazole and pyrazole synthesized from salicylic acid hydrazide and their derivatives evaluate for antitubercular activity [3] , Synthesis and structure modification of salicylic acid hydrazides and modification of thiosemicarbazides of salicylic acid allow the preparation of the new derivatives of triazole and thiazole series and evaluate their various biological activity [4] , analgesic [5] , fungistatic [5] and diuretic [6] activities. Nasr et al [7] synthesized a new series of coumarin bearing hydrazide-hydrazone moiety and evaluated them against human drug-resistant pancreatic carcinoma (Panc-1) cells and drugsensitive (hepatic carcinoma; Hep-G2 and leukemia; CCRF) cell lines in vitro.…”

Section: Introductionmentioning

confidence: 99%