“…Thus, the presented method offers straightforward access to the desired heterocyclic system functionalized not only with simple alkyl and aryl substituents, but also with such functional groups as nitro, cyano, hydroxy, amino, methoxycarbonyl, and sulfide, as well as 1 H -indol-3-yl and halogen(s). Taking into account the easy accessibility of the starting materials and the exceptionally mild reaction conditions, the presented approach can be recommended for the synthesis of title 3-trifluoromethylated heterocycles, and nicely supplements previous reports on the synthesis of 1,2,4-triazin-6(1 H )-ones exploiting amino acids and their derivatives as key building blocks [ 56 , 57 , 59 , 60 , 61 , 62 , 63 , 64 ].…”