Synthesis and structure of an air-stable bis(pentamethylcyclopentadienyl) zirconium pentafluorbezenesulfonate and its application in catalytic epoxide ring-opening reactions

Wang, Lingxiao; Wang, Haojiang; Qiao, Jing; Zhao, Wenjie; Xu, Xinhua; Liang, Zhiwu

doi:10.1016/j.tet.2018.01.016

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Cited by 7 publications

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“…β-Amino alcohols have attracted tremendous interest among natural product synthesis because of the wide existence of their skeleton in drugs, including antihypertensives, antianginal agents, antiasthmatic agents, antimalarial agents, anti-HBV drugs, and so on (Scheme ). β-amino alcohols are considered as promising molecular structures which are widely present in biologically active, natural, and unnatural amino acids . As an intermediate, they can be candidates for heterocyclic organic synthesis, such as indoles and benzoxazines .…”

Section: Introductionmentioning

confidence: 99%

Metal-Free β-Amino Alcohol Synthesis: A Two-step Smiles Rearrangement

Yang

Xie

et al. 2020

J. Org. Chem.

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A novel method for the synthesis of β-amino alcohols has been demonstrated under mild reaction conditions with a broad scope via a two-step Smiles rearrangement. What is more, theoretical calculations have been performed to confirm the rationality of the mechanism. The method has been proved to be notably effective for N-arylated amino alcohols, which are difficult to synthesize by traditional methods.

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