Synthesis and Structure of (1R,2R,8R,9R)-9-[4-(2-methyl-5-chlorophenyl) Piperazino]-14-oxa-7-azatetracyclo[6.6.1.01,11.02,7]pentadeca-11-en-13-one

Unique indolizidine alkaloid securinine is a promising scaffold for the development of neuroprotective and antitumor drugs

“…As a result of nucleophilic addition of amines to securinine, hybrid molecules containing a fragment of the alkaloid securinine and various pharmacophoric amines can be obtained. Thus, a stereospecic method for the production of amino derivatives of securinine 14,30,31,[33][34][35] was developed under the conditions of Lewis acid catalysis (Scheme 1). Various primary, secondary, and cyclic amines have been used to obtain amino derivatives.…”

“…Lin et al describe securinine (1) as a potential neuroprotective agent for the treatment of Alzheimer's disease (AD). Chronic administration of securinine prevented the manifestation of cognitive impairments in rats caused by the administration of the amyloid fragment (Ab [25][26][27][28][29][30][31][32][33][34][35] ). 8,18,19 It may signicantly reduce the inammatory response in glial cells caused by the action of bamyloid protein.…”