Synthesis and structure-activity relationship of Peptide Nucleic Acid Probes with improved Interstrand-Crosslinking abilities: Application to Biotin-mediated RNA-Pulldown
Abstract:The development of interstrand-crosslinking (ICL) probes for the covalent targeting of DNA and RNA sequences of interest has been extensively reported in the past decade. However, most of the reactions reported so far induce the formation of a stable adduct that cannot be reverted, thus ren-dering these chemistries less useful in applications where the reversibility of the reaction is need-ed for further downstream processing of the targeted and isolated sequences, such as enzymatic amplification steps. In thi… Show more
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