“…While no general pre-emptive predictor for AMR has been developed, we and others have shown that computational tools for understanding the underlying molecular mechanisms of mutations can be used to identify likely resistant variants [79] , [80] , [81] , [82] , [86] , [87] , [88] , [89] , [90] , [91] , [92] , [93] , [94] , [95] . This insight has even been used to guide medicinal chemistry design of inhibitors less prone to resistance [96] , [97] , [98] , [99] .…”