Abstract:Numerous heterocyclic compounds containing 3-pyrroline-2-one or pyrrolidine-2,3-dione core have been found in nature and showed valuable biological activities. Therefore, the synthesis of 3-pyrroline-2-one derivatives and pyrrolidine-2,3-dione derivatives have attracted more and more attention from organic chemists and medicinal chemists. In this manuscript, 4-acetyl-3-hydroxy-1-(3-nitrophenyl)-5-phenyl-3-pyrroline-2-one has been prepared via three-component reaction and, besides, two 1,4,5-trisubstituted pyrr… Show more
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