Synthesis and structural characterization of three manganese(III) complexes with N2O2 donor tetradentate Schiff base ligands: Exploration of their catalase mimicking activity

“…Initially, the suspension of 1n is dark blue, but after adding 30% (v/v) hydrogen peroxide, it became faded yellow and rapid evolution of gas was observed, such as in Figures 5(a) – 5(d) . It can be easily understood that the evolved gas is oxygen, and it comes from the catalytic decomposition of hydrogen peroxide solution [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

A Nanostructured Cu(II) Coordination Polymer Based on Alanine as a Trifunctional Mimic Enzyme and Efficient Composite in the Detection of Sphingobacteria

Maldonado

Latorre

Zamora

et al. 2022

Bioinorganic Chemistry and Applications

View full text Add to dashboard Cite

This research raises the potential use of coordination polymers as new useful materials in two essential research fields, allowing the obtaining of a new multiartificial enzyme with the capacity to inhibit the growth of bacteria resistance. The fine selection of the ligands allows the design of a new 2D coordination polymer (CP), with the formula [Cu2(IBA)2(OH2)4]n·6nH2O, by the combination of Cu (II) as the metal center with a pseudoamino acid (H2IBA = isophthaloyl bis β-alanine). Quantitative total X-ray fluorescence (TXRF) analyses show that the obtained CP can gradually release Cu (II) ions. Additionally, this CP can be nanoprocessed and transformed into a metal-organic gel (MOG) by using different Cu (II) salt concentrations and the application of ultrasounds. Considering its nanometric dimensions, the slow Cu (II) release and its simple processability, its performance as an artificial enzyme, and its antibacterial ability were explored. The results obtained show the first nanocoordination polymer acting as an artificial multienzyme (peroxidase, catalase, and superoxodismutase) exhibiting antibacterial activity in the presence of hydrogen peroxide, with selective behavior for three bacterium strains (S. spiritovirum, A. faecales, and B. cereus). Indeed, this CP shows a more robust inhibition capacity for Sphingobacterium. Going beyond that, as there are no comfortable and practically clinical tests capable of detecting the presence of Sphingobacteria, the compound can be easily embedded to form moldable gelatin that will facilitate the handling and low-cost commercial kits.

show abstract

“…The metal complexes were water insoluble; thus, the heterogeneous reaction was applied. [25,26] The H 2 O 2 decomposition was kinetically monitored by titrating out 10 mL of the reaction mixture at different time intervals (each half an hour), against KMnO 4 (0.05 N) in presence of 0.01-M H 2 SO 4 . The consumed volume of KMnO 4 (equivalent to the undecomposed remain H 2 O 2 ) at each time interval was recorded.…”

Section: Catalytic Decomposition Of Hydrogen Peroxidementioning

confidence: 99%

“…Catalase is responsible for the catalytic decomposition of hydrogen peroxide through disproportionation into nontoxic dioxygen and water. [ 25,26 ] Many metal‐based complexes have been used to mimic several enzymes, for example, superoxide dismutase, catalase, and so on. [ 27–30 ]…”

Section: Introductionmentioning

confidence: 99%

“…Catalase is responsible for the catalytic decomposition of hydrogen peroxide through disproportionation into nontoxic dioxygen and water. [25,26] Many metal-based complexes have been used to mimic several enzymes, for example, superoxide dismutase, catalase, and so on. [27][28][29][30] The formation and characteristics of mixed-ligand complexes have received much attention, as they represent new materials for enhancement biological and catalytic features.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis, structural elucidation, and density functional theory investigation of new mononuclear Fe(III), Ni(II), and Cu(II) mixed‐ligand complexes: Biological and catalase mimicking activity exploration

Abdou

Abdel‐Mawgoud

2022

Applied Organom Chemis

View full text Add to dashboard Cite

The present paper deals with synthesis new mononuclear 1:1:1 metal:ligand:co‐ligand complexes, FeLG, NiLG, and CuLG, where L = 1‐{(E)‐[(4‐methylphenyl)imino]methyl}‐2‐naphthol and G = Glycine. The synthesized complexes were characterized based on elemental analysis, Fourier transform infrared spectroscopy (FT‐IR), ultraviolet–visible (UV–vis), mass spectra, molar conductance, magnetic susceptibility, and thermal analysis (TGA) in addition to stoichiometry determination via molar ratio method. The isolated metal complexes showed interesting geometry variation as tetrahedral for CuLG and octahedral for both FeLG and NiLG. The molecular structures of the titled compounds were optimized theoretically using density functional theory (DFT) approach, and the quantum chemical descriptors were calculated. The disk diffusion method was used to investigate the growth inhibition of the titled compounds aganist selected pathogenic bacterial and fungal strains. The metal complexes exhibited higher enhancement as antimicrobial candidates with lower minimum inhibitory concentration (MIC) than the free ligands, and in some cases, the complexes were closed to the standard species. Molecular docking investigation was carried out to ascertain the inhibitory action of the studied compounds against 1HNJ protein, the target enzyme for the antimicrobial agents. The results indicated that the FeLG has the highest binding affinity in comparison with other compounds. Thus, these molecules could be promising antimicrobial candidates. Furthermore, catalase mimicking activity of the complexes has been investigated. The data revealed that CuLG complex catalyzes the decomposition of hydrogen peroxide most effectively. Finally, the quantum chemical parameters of the titled complexes and other different compounds were correlated with their practical biological activity data in a trial to build a SAR model.

show abstract

Synthesis and structural characterization of three manganese(III) complexes with N2O2 donor tetradentate Schiff base ligands: Exploration of their catalase mimicking activity

Cited by 8 publications

References 62 publications

The crystal structure of (azido)-κ¹ N-6,6′-((cyclohexane-1,2-diylbis(azanylylidene)) bis(methanylylidene))bis(3-bromophenolato- κ ⁴ N,N,O,O)-(methanol)-manganese(III)–methanol(1/1), C₂₂H₂₆

The crystal structure of (azido)-κ¹ N-6,6′-((cyclohexane-1,2-diylbis(azanylylidene)) bis(methanylylidene))bis(3-bromophenolato- κ ⁴ N,N,O,O)-(methanol)-manganese(III)–methanol(1/1), C₂₂H₂₆

A Nanostructured Cu(II) Coordination Polymer Based on Alanine as a Trifunctional Mimic Enzyme and Efficient Composite in the Detection of Sphingobacteria

Synthesis, structural elucidation, and density functional theory investigation of new mononuclear Fe(III), Ni(II), and Cu(II) mixed‐ligand complexes: Biological and catalase mimicking activity exploration

Contact Info

Product

Resources

About

Synthesis and structural characterization of three manganese(III) complexes with N2O2 donor tetradentate Schiff base ligands: Exploration of their catalase mimicking activity

Cited by 8 publications

References 62 publications

The crystal structure of (azido)-κ1 N-6,6′-((cyclohexane-1,2-diylbis(azanylylidene)) bis(methanylylidene))bis(3-bromophenolato- κ 4 N,N,O,O)-(methanol)-manganese(III)–methanol(1/1), C 22 H 26

The crystal structure of (azido)-κ1 N-6,6′-((cyclohexane-1,2-diylbis(azanylylidene)) bis(methanylylidene))bis(3-bromophenolato- κ 4 N,N,O,O)-(methanol)-manganese(III)–methanol(1/1), C 22 H 26

A Nanostructured Cu(II) Coordination Polymer Based on Alanine as a Trifunctional Mimic Enzyme and Efficient Composite in the Detection of Sphingobacteria

Synthesis, structural elucidation, and density functional theory investigation of new mononuclear Fe(III), Ni(II), and Cu(II) mixed‐ligand complexes: Biological and catalase mimicking activity exploration

Contact Info

Product

Resources

About

The crystal structure of (azido)-κ¹ N-6,6′-((cyclohexane-1,2-diylbis(azanylylidene)) bis(methanylylidene))bis(3-bromophenolato- κ ⁴ N,N,O,O)-(methanol)-manganese(III)–methanol(1/1), C₂₂H₂₆

The crystal structure of (azido)-κ¹ N-6,6′-((cyclohexane-1,2-diylbis(azanylylidene)) bis(methanylylidene))bis(3-bromophenolato- κ ⁴ N,N,O,O)-(methanol)-manganese(III)–methanol(1/1), C₂₂H₂₆