Synthesis and structural characterization of C,N-benzimidazole based ruthenium(II) complex with in vitro anticancer activity

Kumarasamy, Keerthika; Devendhiran, Tamiloli; Shibu, Marthandam Asokan; Ramaswamy, Mahendran; Lin, Mei–Ching; Chien, Wei‐Jyun; Ramasamy, Selva Kumar; Huang, Chih‐Yang

doi:10.1016/j.inoche.2023.110662

Cited by 8 publications

(1 citation statement)

References 53 publications

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“…The infrared visible spectra of the half-sandwich ruthenium complexes 1 – 4 all showed a broad absorption band in the range of 1585–1614 cm –1 , which is the characteristic absorption peak of the CN bond on the indazole ring. Compared with the free 2-phenyl-2 H -indazole ligands (1593–1626 cm –1 ), the CN bond telescopic vibration band of the complexes shifted to lower frequencies, indicating that the binding of ruthenium metal to the ligand could reduce the central electron density of the CN bond, thereby reducing the absorption frequency during complexation, confirming the existence of pseudo-octahedral surroundings in the metal center …”

Section: Resultsmentioning

confidence: 99%

Cyclometalated Half-Sandwich Ruthenium Complexes: Preparation, Structure, and Catalytic Synthesis of Phenolic Esters from Aryl Halides without Using External CO under Air

Yang,

Guan,

et al. 2023

Inorg. Chem.

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A series of cyclometalated C,N-chelate halfsandwich ruthenium complexes based on N-heterocyclic ligands were prepared through a simple route with good yields. These airand moisture-stable cyclometalated ruthenium complexes showed excellent catalytic efficiency in phenoxy carbonylation of aryl halides with phenyl formate derivatives as a CO source and phenol as a coupling partner under air. Ester products were obtained with high yields at room temperature and without the need for an inert atmosphere. The excellent catalytic activity, broad substrate range, and mild reaction conditions made this catalytic system potential for industrial production. In addition, DFT study has been carried out to elaborate the possible mechanism of this Ru-catalyzed reaction.

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Section: Resultsmentioning

confidence: 99%

Cyclometalated Half-Sandwich Ruthenium Complexes: Preparation, Structure, and Catalytic Synthesis of Phenolic Esters from Aryl Halides without Using External CO under Air

Yang,

Guan,

et al. 2023

Inorg. Chem.

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Cyclometalated half‐sandwich iridium complexes: Synthesis, characterization, and catalytic activity in preparation of esters from halides by using formate as both CO source and coupling partner

Gao,

Cao,

Luo

et al. 2024

Applied Organom Chemis

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A highly efficient carbonylation of aryl halides using half‐sandwich iridium catalysis was developed, providing a new avenue for synthesizing carboxylic ester derivatives and yielding consistently impressive results. These iridium complexes demonstrated remarkable catalytic performance in the coupling reaction using phenyl formate derivatives as the source of CO, phenol, and aryl halides as the starting material in the presence of air and possessed good air and moisture stability properties. Ester products with different substituents were synthesized at low reaction temperatures without the need for an inert atmosphere, leading to high yields. The broad substrate scope, impressive catalytic activity, and mild reaction conditions suggest promising industrial applications for this catalytic system. The desired metal complexes 1–4 have been well proven by attenuated total reflectance‐Fourier transform infrared (ATR‐FTIR), nuclear magnetic resonance (NMR), and elemental analysis (EA). The molecular structure of the cyclometalated iridium complexes 2 and 3 was proven through X‐ray crystallography. Additionally, the possible mechanism of this Ir‐catalyzed process is further supported by the density functional theory (DFT) study.

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Transition metal complexes of benzimidazole-based ligands: Synthesis, characterization, biological, and catecholase activities

Nouman,

Rana,

Ahmedi

et al. 2025

Inorganica Chimica Acta

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Synthesis and structural characterization of C,N-benzimidazole based ruthenium(II) complex with in vitro anticancer activity

Cited by 8 publications

References 53 publications

Cyclometalated Half-Sandwich Ruthenium Complexes: Preparation, Structure, and Catalytic Synthesis of Phenolic Esters from Aryl Halides without Using External CO under Air

Cyclometalated Half-Sandwich Ruthenium Complexes: Preparation, Structure, and Catalytic Synthesis of Phenolic Esters from Aryl Halides without Using External CO under Air

Cyclometalated half‐sandwich iridium complexes: Synthesis, characterization, and catalytic activity in preparation of esters from halides by using formate as both CO source and coupling partner

Transition metal complexes of benzimidazole-based ligands: Synthesis, characterization, biological, and catecholase activities

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