Synthesis and structural characterization of dimeric phosphine ylide Cu(I) complexes: Application in Suzuki cross-coupling reactions and biological evaluation as antibacterial agents

Sabounchei, Seyyed Javad; Pourshahbaz, Mahbubeh; Hashemi, Ali; Ahmadi, Mohsen; Karamian, Roya; Asadbegy, Mostafa; Khavasi, Hamid Reza

doi:10.1016/j.jorganchem.2014.03.017

Cited by 28 publications

(15 citation statements)

References 73 publications

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“…In this regard, copper has attracted significant interest, since it plays key roles in biochemical processes such as nitrite reductase22, amine oxidases23, superoxide dismutase24, catechol oxidase25 and tyrosinase26. Copper(II) complexes have been intensily studied1027 whereas the potential of Cu(I) complexes has been scarcely tested as antimicrobial28, antiviral29, antifungal30 and anticancer drugs1731323334. Mostly, coordination compounds having S-/N-donor and/or phosphine ligands are highly suitable candidates for clinical investigation, given their proven cytotoxicity on cancer cells and high stability in aqueous solution35.…”

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confidence: 99%

Heteroleptic Copper(I) Complexes of “Scorpionate” Bis-pyrazolyl Carboxylate Ligand with Auxiliary Phosphine as Potential Anticancer Agents: An Insight into Cytotoxic Mode

Khan

Usman

Dhivya

et al. 2017

Sci Rep

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New copper(I) complexes [CuCl(PPh3)(L)] (1: L = LA = 4-carboxyphenyl)bis(3,5-dimethylpyrazolyl)methane; (2: L = LB = 3-carboxyphenyl)bis(3,5-dimethylpyrazolyl)methane) were prepared and characterised by elemental analysis and various spectroscopic techniques such as FT-IR, NMR, UV–Vis, and ESI-MS. The molecular structures of complexes 1 and 2 were analyzed by theoretical B3LYP/DFT method. Furthermore, in vitro DNA binding studies were carried out to check the ability of complexes 1 and 2 to interact with native calf thymus DNA (CT-DNA) using absorption titration, fluorescence quenching and circular dichroism, which is indicative of more avid binding of the complex 1. Moreover, DNA mobility assay was also conducted to study the concentration-dependent cleavage pattern of pBR322 DNA by complex 1, and the role of ROS species to have a mechanistic insight on the cleavage pattern, which ascertained substantial roles by both hydrolytic and oxidative pathways. Additionally, we analyzed the potential of the interaction of complex 1 with DNA and enzyme (Topo I and II) with the aid of molecular modeling. Furthermore, cytotoxic activity of complex 1 was tested against HepG2 cancer cell lines. Thus, the potential of the complex 1 is promising though further in vivo investigations may be required before subjecting it to clinical trials.

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confidence: 99%

Heteroleptic Copper(I) Complexes of “Scorpionate” Bis-pyrazolyl Carboxylate Ligand with Auxiliary Phosphine as Potential Anticancer Agents: An Insight into Cytotoxic Mode

Khan

Usman

Dhivya

et al. 2017

Sci Rep

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“…298 Other metals such as mercury(II) 299,300 and copper(I) were investigated for the synthesis of similar complexes. 301 The antimicrobial activity of these compounds was also evaluated. Ning and co-workers described substitution reactions using preformed ylides for the preparation of molybdenum complexes bearing triphenylcyclopentadienylide ligands.…”

Section: Coordination Chemistrymentioning

confidence: 99%

Phosphonium salts and P-ylides

Selva¹,

Perosa²,

Fiorani³

2018

Organophosphorus Chemistry

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“…298 Other metals such as mercury(II) 299,300 and copper(I) were investigated for the synthesis of similar complexes. 301 The antimicrobial activity of these compounds was also evaluated.…”

Section: Coordination Chemistrymentioning

confidence: 99%