Synthesis and structural characterization of antimicrobial binuclear copper(II) coordination compounds bridged by hydroxy- and/or thiodipropionic acid

Buchtelová, Hana; Škubalová, Zuzana; Strmiska, Vladislav; Michálek, Petr; Kočiová, Silvia; Šmerková, Kristýna; Kruszyński, Rafał; Bieńko, Alina; Kaj, Michalina; Lewińska, Agnieszka; Bieńko, Dariusz C.; Malik, Magdalena; Milosavljević, Vedran; Kopel, Pavel; Heger, Zbyněk; Adam, Vojtěch

doi:10.1016/j.jinorgbio.2018.10.011

Cited by 6 publications

(4 citation statements)

References 57 publications

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“…Coordination between the central metal atom and the ligand, covalent or non-covalent interactions, or both contribute to the stabilization of these polymers [ 51 ]. The non-covalent interactions in these networks are hydrogen bonding [ 52 ], where they are often O-H···O interactions, C-H···O interactions [ 53 ], and N-H···O interactions [ 54 ]. There are cases where 3D networks are stabilized by hydrogen bonds between other atoms, e.g., sulfur atoms of the thioether group.…”

Section: Biologically Active Copper Zinc and Nickel Coordination Comp...mentioning

confidence: 99%

“…The monodentate thiodipropionic acid anion is the bridging ligand in the complex [Cu 2 (pmdien) 2 (H 2 O) 2 ( μ -tdp)](ClO 4 ) 2 ·H 2 O [ 53 ]. The presence of hydrogen bonds, O-H···O interactions, causes the formation of a helix-shaped chain, but this type of bonding is not the only one found in this complex.…”

Section: Copper Zinc and Nickel Dicarboxylate Compoundsmentioning

confidence: 99%

“…Under these assumptions, the expected activity in combination therapy for metastasis is under further study. It stimulates the expression of MT-1/2 and MT-3, leading to the maintenance of cellular metal homeostasis and metal detoxification [ 53 ].…”

Section: Copper Zinc and Nickel Dicarboxylate Compoundsmentioning

confidence: 99%

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Coordination Compounds of Cu, Zn, and Ni with Dicarboxylic Acids and N Donor Ligands, and Their Biological Activity: A Review

Loubalová

Kopel

2023

Molecules

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Complexes of carboxylic acids are very often studied due to their interesting structural, spectral, and magnetic properties. This review is focused on complexes of four dicarboxylic acids, namely, 2,2′-thiodioacetic, 3,3′-thiodipropionic, 3,3′-dithiodipropionic, and fumaric acid. Many of the complexes were characterized by single crystal X-ray analyses. Without the analyses, it is very difficult to predict the coordination mode of carboxylate groups or nitrogen ligands on central atoms. Thus, structural properties are also discussed, as well as potential applications.

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Section: Biologically Active Copper Zinc and Nickel Coordination Comp...mentioning

confidence: 99%

Section: Copper Zinc and Nickel Dicarboxylate Compoundsmentioning

confidence: 99%

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Coordination Compounds of Cu, Zn, and Ni with Dicarboxylic Acids and N Donor Ligands, and Their Biological Activity: A Review

Loubalová

Kopel

2023

Molecules

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“…Hemolytic Assay. Hemolytic assay was performed on human red blood cells samples (RBCs) according to Buchtelova et al 29 RBCs were taken from healthy human donor who signed informed consent. The RBC samples were washed five times with 150 mM NaCl and then treated with CAPS containing DOX in concentration range from 0−50 μg mL −1 .…”

Section: Size Distribution and ζ-Potentialmentioning

confidence: 99%

Encapsulation of Doxorubicin in Furcellaran/Chitosan Nanocapsules by Layer-by-Layer Technique for Selectively Controlled Drug Delivery

et al. 2019

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Minimization of drug side effects is a hallmark of advanced targeted therapy. Herein we describe the synthesis of polysaccharide-based nanocapsules prepared from furcellaran and chitosan via layer-by-layer deposition using electrostatic interaction. Using doxorubicin as a model drug, prepared nanocapsules showed excellent drug loading properties and release influence by pH and stability. Targeted delivery of doxorubicin was achieved by nanocapsule surface modification using homing peptide (seq SMSIARLC). The synthesized nanocapsules possess excellent compatibility to eukaryotic organisms. In the case of nonmalignant cells (PNT1A and HEK-293), toxicity tests revealed the absences of DNA fragmentation, apoptosis, necrosis, and also disruption of erythrocyte membranes. In contrast, results from treatment of malignant cell lines (MDA-MB-231 and PC3) indicate good anticancer effects of synthesized bionanomaterial. Internalization studies revealed the nanocapsule's ability to enter the malignant cell lines by endocytosis and triggering the apoptosis. The occurrence of apoptosis is mostly connected to the presence of ROS and inability of DNA damage reparation. Additionally, the obtained results strongly indicate that peptide modification increases the speed of nanocapsule internalization into malignant cell lines while simultaneously nonmalignant cell lines are untouched by nanocapsules highlighting the strong selectivity of the peptide.

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Discovery of metal-based complexes as promising antimicrobial agents

Liang

Sun

Yang

et al. 2021

European Journal of Medicinal Chemistry

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Synthesis and structural characterization of antimicrobial binuclear copper(II) coordination compounds bridged by hydroxy- and/or thiodipropionic acid

Cited by 6 publications

References 57 publications

Coordination Compounds of Cu, Zn, and Ni with Dicarboxylic Acids and N Donor Ligands, and Their Biological Activity: A Review

Coordination Compounds of Cu, Zn, and Ni with Dicarboxylic Acids and N Donor Ligands, and Their Biological Activity: A Review

Encapsulation of Doxorubicin in Furcellaran/Chitosan Nanocapsules by Layer-by-Layer Technique for Selectively Controlled Drug Delivery

Discovery of metal-based complexes as promising antimicrobial agents

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