Synthesis and Structural Characterisation of a Novel Chiral ansa-Cobaltocenium Hexafluorophosphate

Abstract

Keywords: Metallocenes / Structural analysis / Density functional calculations / Cobalt (1) was synthesised and its structure derived by X-ray crystallography and spectroscopic methods in conjunction with theoretical calculations. To gain an insight into the effect of these bridging atoms and the exocyclic substituents on the sandwich structure, a study was undertaken in which comparisons were drawn between this ansa-cobaltocenium ion and other previously reported struc-

Anticancer drugs based on alkenyl and boryl substituted titanocene complexes

“…Different research groups have developed alternative synthetic routes starting from fulvenes [42][43][44][45] to obtain ansa-titanocene complexes with a carbon-carbon bridge [46][47][48][49] as well as a variety of other substituted complexes [50][51][52][53][54][55][56][57][58][59][60][61][62][63][64], all of which were tested as anticancer agents.…”

Cytotoxic studies of substituted titanocene and ansa-titanocene anticancer drugs

“…Synthesis starting from titanium dichloride and fulvenes [42][43][44][45] led to substituted ansa-titanocenes with a carbon-carbon bridge [46][47][48][49]. Using similar synthetic paths, many different substituted complexes were prepared and tested as anticancer drugs [50][51][52][53][54][55][56][57][58][59][60][61][62][63][64].…”

Novel benzyl substituted titanocene anti-cancer drugs

“…Very recently, more synthetic effort has been employed to increase the cytotoxicity of titanocene dichloride derivatives [8][9][10][11][12]. A novel method starting from titanium dichloride and fulvenes [13][14][15][16] allows direct access to highly substituted ansa-titanocenes [17][18][19][20]. By using this method we have synthesised [1,2-di(cyclopentadienyl)-1,2-di-(4-N,N-dimethylaminophenyl)-ethanediyl]titanium dichloride (4, Titanocene X), which has an IC 50 value of 2.7 · 10 À4 M when tested for cytotoxic effects on the LLC-PK cell line.…”