Synthesis and Stability Study on an Aspirin Derivative With Potential Selective Cox-2 Inhibitor

Abstract

The synthesis of N-[5-Methyl-2-(1, 3, 4 COX-2 selective inhibitor and the preliminary kinetic study for hydrolysis of this compound is studied in this paper. The compound was prepared from the corresponding aspirin and 2-amino-5-methyl-1,3,4thiadiazole in the presence of N,N-dicyclohexylcarbodiimide (DCC) as coupling agent. The preliminary kinetic study for hydrolysis of this compound and the effect of pH on the rate of hydrolysis in buffer solution citrate-phosphate-borate/HCl was studied. The structure was confirmed by infrared, nuclear magnetic resonance (H-NMR), and elemental microanalysis assay. The compound underwent slightly hydrolysis at low and high pH with a fairly stabile so, provide a chance for it to be absorbed intact with highly bioavailability, longer half life, and with lower G1 toxicity.