Synthesis and Stability of Highly Crystalline and Stable Iron/Iron Oxide Core/Shell Nanoparticles for Biomedical Applications

Cheong, Soshan; Ferguson, Peter M.; Hermans, Ian F.; Jameson, Guy N. L.; Prabakar, Sujay; Herman, D. A.; Tilley, Richard D.

doi:10.1002/cplu.201100074

Cited by 39 publications

(36 citation statements)

References 38 publications

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Section: Resultsmentioning

confidence: 99%

“…All the mice were in good condition, which suggested that injected MNPs do not possess tumorigenic activity, and may not exert any acute toxic effects on the recipient. Therefore, it may be inferred that these MNPs can serve as an effective contrast agent, suitable for MRI (32,33). These images indicated that, after injection of iron oxide, the signal intensity of the solid tumor group was lower than that of the control group.…”

Section: Tumorigenic Assessmentmentioning

confidence: 94%

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Increased transverse relaxivity in ultrasmall superparamagnetic iron oxide nanoparticles used as MRI contrast agent for biomedical imaging

Mishra

Kumar

Khushu

et al. 2016

Contrast Media & Molecular

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Synthesis of a contrast agent for biomedical imaging is of great interest where magnetic nanoparticles are concerned, because of the strong influence of particle size on transverse relaxivity. In the present study, biocompatible magnetic iron oxide nanoparticles were synthesized by co-precipitation of Fe and Fe salts, followed by surface adsorption with reduced dextran. The synthesized nanoparticles were spherical in shape, and 12 ± 2 nm in size as measured using transmission electron microscopy; this was corroborated with results from X-ray diffraction and dynamic light scattering studies. The nanoparticles exhibited superparamagnetic behavior, superior T relaxation rate and high relaxivities (r = 18.4 ± 0.3, r = 90.5 ± 0.8 s mM , at 7 T). MR image analysis of animals before and after magnetic nanoparticle administration revealed that the signal intensity of tumor imaging, specific organ imaging and whole body imaging can be clearly distinguished, due to the strong relaxation properties of these nanoparticles. Very low concentrations (3.0 mg Fe/kg body weight) of iron oxides are sufficient for early detection of tumors, and also have a clear distinction in pre- and post-enhancement of contrast in organs and body imaging. Many investigators have demonstrated high relaxivities of magnetic nanoparticles at superparamagnetic iron oxide level above 50 nm, but this investigation presents a satisfactory, ultrasmall, superparamagnetic and high transverse relaxivity negative contrast agent for diagnosis in pre-clinical studies. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Resultsmentioning

confidence: 99%

Section: Tumorigenic Assessmentmentioning

confidence: 94%

Increased transverse relaxivity in ultrasmall superparamagnetic iron oxide nanoparticles used as MRI contrast agent for biomedical imaging

Mishra

Kumar

Khushu

et al. 2016

Contrast Media & Molecular

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show abstract

“…[1][2][3][4] For the effective application of magnetic nanoparticles, fine and reproducible size control is essential. [5][6] For example, a number of biomedical applications (e.g., magnetic relaxometry, 7-8 magnetic particle imaging (MPI), [9][10] magnetic hyperthermia [11][12] ) rely on the superparamagnetic relaxation of magnetic nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Nanoparticle Size Control by Extending LaMer’s Mechanism

et al. 2015

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The synthesis of well-defined nanoparticle materials has been an area of intense investigation, but size control in nanoparticle syntheses is largely empirical. Here, we introduce a general method for fine size control in the synthesis of nanoparticles by establishing steady state growth conditions through the continuous, controlled addition of precursor, leading to a uniform rate of particle growth. This approach, which we term the "Extended LaMer Mechanism" allows for reproducibility in particle size from batch to batch, as well as the ability to predict nanoparticle size by monitoring the early stages of growth. We have demonstrated this method by applying it to a challenging synthetic system: magnetite nanoparticles. To facilitate this reaction, we have developed a reproducible method for synthesizing an iron oleate precursor that can be used without purification. We then show how such fine size control affects the performance of magnetite nanoparticles in magnetic hyperthermia.

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“…[1][2][3][4][5][6] Typically, iron oxide based nanoparticles have been increasingly used in a broad range of applications, for example, as contrast agents in magnetic resonance imaging (MRI), [6,7] targeted drug delivery, [6] electrochemical and biosensors [8][9][10] and as electrode materials for semiconductor gas sensors. [1][2][3][4][5][6] Typically, iron oxide based nanoparticles have been increasingly used in a broad range of applications, for example, as contrast agents in magnetic resonance imaging (MRI), [6,7] targeted drug delivery, [6] electrochemical and biosensors [8][9][10] and as electrode materials for semiconductor gas sensors.…”

Section: Introductionmentioning

confidence: 99%

The Oxygen Reduction Reaction in Ferrofluids: Towards Membrane‐less and Spill‐less Gas Sensors

Panchompoo¹,

Ge²,

Zhao³

et al. 2014

ChemPlusChem

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In this study, a “membrane‐less and spill‐less” gas‐sensing device has been evaluated for the electrochemical detection of oxygen. Iron oxide magnetic nanoparticles were prepared by chemical co‐precipitation and used to prepare an aqueous ferrofluid. The iron oxide nanoparticles were subsequently stabilised and passivated with a cationic polymer, namely, poly(diallyldimethyl ammonium chloride). The resulting ferrofluid was evaluated as an electrolyte for the analytical quantification of oxygen on screen‐printed carbon electrodes. An applied magnetic field immobilised the ferrofluid electrolyte in place to result in a “membrane‐less and spill‐less” ferrofluid‐based gas sensor. The polymer poly(diallyldimethyl ammonium chloride) was found to result in an apparent enhancement in the electrocatalysis of the system towards the oxygen reduction reaction. Furthermore, as the strength of the applied magnetic field was increased, the oxygen reduction current also increased owing to the response of the polymer‐coated nanoparticles. The oxygen reduction current was linear from 0 to 100 % oxygen content.

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Synthesis and Stability of Highly Crystalline and Stable Iron/Iron Oxide Core/Shell Nanoparticles for Biomedical Applications

Cited by 39 publications

References 38 publications

Increased transverse relaxivity in ultrasmall superparamagnetic iron oxide nanoparticles used as MRI contrast agent for biomedical imaging

Increased transverse relaxivity in ultrasmall superparamagnetic iron oxide nanoparticles used as MRI contrast agent for biomedical imaging

Enhanced Nanoparticle Size Control by Extending LaMer’s Mechanism

The Oxygen Reduction Reaction in Ferrofluids: Towards Membrane‐less and Spill‐less Gas Sensors

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