Synthesis and Spectroscopic Characterization of Some New Biological Active Azo–Pyrazoline Derivatives

Hawaiz, Farouq E.; Samad, Mohammed K.

doi:10.1155/2012/525940

Cited by 25 publications

(24 citation statements)

References 12 publications

(15 reference statements)

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“…Sediaan tersebut memiliki daya sebar 5-7 cm. 14,15 Berdasar hasil uji daya sebar krim ekstrak daun L. camara Linn. 3%, 4% dan 5% setelah disimpan selama 1 tahun masih bisa digunakan akan tetapi menimbulkan rasa yang kurang nyaman karena akan terasa tebal di kulit.…”

Section: Pembahasanunclassified

Krim ekstrak daun Lantana camara Linn. 4% stabil setelah disimpan selama 1 tahun

Mahardhitya¹,

Parwanto²

2018

J Biomedika Kesehat

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ABSTRAK LATAR BELAKANGTumbuhan mengandung metabolit sekunder yang dapat berpotensi sebagai antioksidan, diantaranya adalah alkaloid, flavonoid, senyawa fenol, steroid, dan terpenoid. Lantana camara Linn. (tembelekan) merupakan tanaman liar yang tumbuh tanpa perawatan khusus yang digunakan masyarakat secara empiris untuk mengobati beberapa macam penyakit. Penelitian ini bertujuan untuk melihat perbandingan kadar flavonoid krim ekstrak daun L. camara Linn. 3%, 4%, 5% setelah disimpan selama 1 tahun. METODEPenelitian ini merupakan studi observasional dengan desain potong lintang yang menggunakan krim ekstrak daun L. camara Linn. 3%, 4% dan 5%. Pengukuran pH, daya sebar dan uji organoleptik dilakukan di Laboratorium Biologi, Fakultas Kedokteran, Universitas Trisakti, sedangkan pengukuran kadar flavonoid dilakukan di Laboratorium Pengujian Penelitian Terpadu UGM. Pengukuran kadar flavonoid terhadap ketiga sampel tersebut menggunakan spektrofotometer. Data yang diperoleh diuji normalitas dan homogenitasnya. Apabila data normal dan homogen dilanjutkan dengan uji one way anova, apabila data tidak normal dan atau tidak homogen dilakukan uji Kruskall-Wallis dengan tingkat kemaknaan 0,05. HASILKrim ekstrak daun L. camara Linn. 3%, 4% dan 5% memiliki pH yang sama yaitu 6. Daya sebar krim ekstrak daun L. camara Linn. 3% sebesar 2.44 senti meter (cm), sedangkan untuk krim ekstrak daun L. camara Linn. 4% sebesar 2.12 cm dan krim ekstrak daun L. camara Linn. 5% sebesar 2.29 cm. Hasil uji organoleptik terhadap krim ekstrak daun L. camara Linn. 3%, 4% dan 5% memperlihatkan bentuk sediaan setengah padat, warna hijau tua dan bau khas ekstrak. Setelah disimpan selama 1 tahun, perubahan kadar flavonoid pada krim ekstrak daun L. camara Linn. 3%, 4% dan 5% masing-masing sebesar +85.6%, -1.07% dan +54.7% (p=0.001). KESIMPULANSetelah disimpan selama 1 tahun, krim ekstrak daun L. camara Linn. 3%, 4% dan 5% memiliki pH 6, masing-masing krim memiliki daya sebar dan organoleptik yang sama. Krim ekstrak daun L. camara Linn. 4% paling stabil dibanding krim ekstrak daun L. camara Linn. 3% dan 5%. Lantana camara Linn. leaf extracts cream of 4% stable after being stored for 1 year BACKGROUND Plants contain secondary metabolite that potentially acts as anti-oxidant, such as alcaloid, flavonoid, phenol compunds, steroid, dan terpenoid. Lantana camara Linn. is a wild plant without special treatmens, which is generally used for empiric medicine. Objective of this study to determine the distinction of flavonoid levels in Lantana camara Linn. leaf extracts cream of 3%, 4%, 5% after being stored for 1 year.

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Section: Pembahasanunclassified

Krim ekstrak daun Lantana camara Linn. 4% stabil setelah disimpan selama 1 tahun

Mahardhitya¹,

Parwanto²

2018

J Biomedika Kesehat

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“…Classical Method (Hawaiz and Samad, 2012) A mixture of newly prepared curcumin analogues (2a-e) (1 mmol), hydrazine hydrate (2 mmoles) and sodium hydroxide (0.1 g, 2.5 mmol) in methanol (20 mL) was refluxed with stirring for (3-4 h) until complete the reaction which was monitored by change the color to green in testing with drops of H 2 SO 4 . The ppt.…”

Section: (Omp-(substitutedbenzyloxy)phenyl)-3-(omp-(substitutementioning

confidence: 99%

Ultrasound-assisted Synthesis of Some New Curcumin Analogs and Their Corresponding Pyrazoline Derivatives

Hawaiz

Omer

2017

ARO

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Abstract-In this work, a series of new curcumin mono-carbonyl analogs containing benzyloxy moieties and their pyrazoline derivatives were synthesized using a green method (ultrasound assisted technique) along with traditional method. The work also includes a comparison between the two methods together and with the reported results. Remarkable improvements were achieved by dropping down the reaction time from hours to minutes and obtaining higher yields of the products.

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“…is completed. The solid azo dye was collected by vacuum filtration, washed several times with water and cold ethanol, dried and recrystallized from xylene to obtain yellow crystals, of 5-(4-chlorophenyl azo)-2-hydroxy acetophenone [23]. …”

Section: Preparation Of Starting Materials 2-(hydroxyl)-5-[4-chlorophementioning

confidence: 99%

Design, synthesis, and spectroscopic study of some new flavones containing two azo linkages

Ayoob

Hawaiz

2017

AIP Conference Proceedings

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Abstract. In the present study; 5-(4-chlorophenyl azo) -2-hydroxy acetophenone (1) was prepared by diazotization of 4-chloro aniline and its coupling reaction with 2-hydroxy acetophenone, then reacted with different azo benzyloxy benzaldehydes(3a-i) to give new synthesized 2-hydroxy chalcones(4a-i). The later compounds were subjected to oxidative cyclization by catalytic amount of I 2 in DMSO affording the target molecules new flavones bearing two azolinkages (5a-i). The structures of the newly synthesized compounds were identified on the bases of their FT-IR, 1 H-NMR, 13 C-NMR and DEPT-135 spectra. The synthesized Flavone derivatives were evaluated against two types of bacteria gram positive (Staphylococcus aurous) and gram negative (Pseudomonas aeruginosa). The results showed that most of the synthesized flavones are more sensitive against (G -ve) bacteria than (G +ve) bacteria.

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Synthesis and Spectroscopic Characterization of Some New Biological Active Azo–Pyrazoline Derivatives

Abstract: A number of 3-[4-(benzyloxy)-3-(2-Chlorophenylazo)-phenyl]-5-

Cited by 25 publications

References 12 publications

Krim ekstrak daun Lantana camara Linn. 4% stabil setelah disimpan selama 1 tahun

Krim ekstrak daun Lantana camara Linn. 4% stabil setelah disimpan selama 1 tahun

Ultrasound-assisted Synthesis of Some New Curcumin Analogs and Their Corresponding Pyrazoline Derivatives

Design, synthesis, and spectroscopic study of some new flavones containing two azo linkages

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