Synthesis and spectral characteristics of 1,4-diaryl-2-arylidenebenzhydrazidines

Attempts to Access a Series of Pyrazoles Lead to New Hydrazones with Antifungal Potential against Candida species including Azole-Resistant Strains

“…The general procedure was used with 2-(4-bromobenzylidene)malononitrile 3c (0.5 g) and phenylhydrazine 4m (0.21 mL) to obtain pure compound 1n as a white solid with the same NMR spectra as previously described [ 17 ] (0.36 g, 61% yield); mp (EtOH) 121–123 °C (lit. mp 116–117 °C) [ 17 ]; R f (EtOAc:Cyclohexane 1:1) = 0.62.…”

“…The general procedure was used with 2-(4-bromobenzylidene)malononitrile 3c (0.5 g) and phenylhydrazine 4m (0.21 mL) to obtain pure compound 1n as a white solid with the same NMR spectra as previously described [ 17 ] (0.36 g, 61% yield); mp (EtOH) 121–123 °C (lit. mp 116–117 °C) [ 17 ]; R f (EtOAc:Cyclohexane 1:1) = 0.62. 1 H-NMR (CDCl 3 , 500 MHz) δ ppm 6.88–6.91 (m, 1H, Ar H ), 7.11 (dd, J = 9.0, 1.0 Hz, 2H, 2Ar H ), 7.27–7.30 (m, 2H, 2Ar H ), 7.48–7.53 (m, 5H, 4Ar H + N H ), 7.61 (s, 1H, =C H ).…”

“…The general procedure was used with 2-(4-bromobenzylidene)malononitrile 3c (0.5 g) and phenylhydrazine 4m (0.21 mL) to obtain pure compound 1n as a white solid with the same NMR spectra as previously described [17]…”