Synthesis and special characterization through X-ray analysis of 1,8-dioxooctahydroxanthenes

Vibrational spectroscopic studies, theoretical aspects, and X‐ray analysis of xanthenodiones (1,8‐dioxooctahydroxanthenes)

“…The compounds 1 and 2 were synthesized using solvent free reactions catalyzed by ZrOCl 2 ·8H 2 O (Scheme 1), as previously described. [ 16,25,26,36 ] The formation of these compounds involved Knoevenagel condensation reaction between aromatic aldehydes and two β ‐diketones, followed by Michael addition, and finally dehydration.…”

“…[ 13 ] Despite being a class of compounds that have been widely studied from the preparation point of view, investigations on the structural features of xanthenodiones are less common. [ 14–24 ] Within this context and considering our interest in the chemistry, bioactivities, and structural features of xanthenodiones, [ 16,25,26 ] we herein describe the synthesis and characterization of two hydroxylated xanthenodiones. Their full characterization was achieved using nuclear magnetic resonance (NMR), single‐crystal, X‐ray diffraction, infrared (IR), and Raman spectroscopy techniques along with mass spectrometry.…”

Design and fabrication of photoactive imidazole-based poly(ether-imide)s and a polyimide/HBP-modified SiO2 composite: toward high heat-resistance, antimicrobial activity and removal of heavy metal ions

“… 32–36 Imidazole and xanthene rings can be classified as one of the most prominent heterocyclic scaffolds in many fields including medicine and organic chemistry. 37,38 The polar imidazole ring has two nitrogens, which easily dissolve in a polar solvent and aqueous solutions. These compounds and their derivatives with their unique properties such as stability to hydrogenation, consistency in harsh bases and acids, high thermal and chemical stability, 39 and structural stiffness have claimed a central position in pharmacological activities and chemistry.…”

Evaluation of Antiviral Activity of Cyclic Ketones against Mayaro Virus

“…Other important cyclic ketones are the xanthenodiones [or 1,8-dioxo-octahydro-xanthenes] characterized by the presence of a pyran-nucleus fused to a cyclohexe-2-one ring on both sides. These compounds present a variety of biological functions, including anti bactericidal, leishmanicidal, antifungal, antitumoral, and tripanocidal activities [33,34]. Xanthenodiones resemble xanthones, a class of natural compounds known for their numerous pharmacological applications including antiviral, antimicrobial, hepatoprotective, anticancer, antioxidant, and anti-inflammatory applications [35].…”