Synthesis and Some Pharmacological Studies of New Benzenesulfonamide Derivatives

Synthesis of Some New Benzisothiazolone and Benzenesulfonamide Derivatives of Biological Interest Starting from Saccharin Sodium

“…In this work, the novel benzenesulfonamide derivatives ( 4a – f , 5a – b , 6 , and 7 ) were prepared as shown in Scheme . N ‐Isopropyl saccharin ( 2 ) was prepared via the reaction of isopropyl iodide with sodium saccharin by heating the reactants in dimethylformamide (DMF) for 2 h according to the reported procedure .…”

“…The hydrazide key intermediate 3 was prepared by stirring N ‐isopropyl saccharin ( 2 ) with excess hydrazine hydrate at room temperature for 10–20 min as the reported method . The hydrazide 3 was condensed with different aromatic aldehydes via heating the reactants at reflux in ethanol containing catalytic amount of glacial acetic acid for 2 h to afford the novel hydrazone derivatives ( 4a – f ).…”

Synthesis and biological activity of substituted amides and hydrazides of 1,4-dicarboxylic acids (a review)

“…Some N-aminomaleimides Vb (X = NHAr, NHCOAr, N=CHAr) possess antiinflammatory and analgesic properties [28], exhibit antimicrobial and antifungal action [22], and are used as herbicides [19,26]. The chemical properties and biological activity of reactive isoimides X and XI (isomeric to compounds V and VI, respectively), which are formed upon the dehydration of compounds II and III under mild conditions (Scheme 2) [4, 8, 29 -32] will be considered in a separate publication.…”