Synthesis and Some Pharmacological Properties of N-Benzoyl-α,β-dehydrotyrosine-Containing Dipeptides

Topuzyan, V. O.; Hovhannisyan, A. A.; Makichyan, A. T.; Hunanyan, Lernik

doi:10.1134/s1070363222050115

Cited by 6 publications

(1 citation statement)

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“…In the method we employed, a specific reaction mixture acted as our control. [41,42] This mixture comprised AChE and plasmic BuChE, and a reaction medium containing water, 0.1 M phosphoric acid, DTNB, and DMSO as the solvent.…”

Section: The Anticholinestetrase Propertiesmentioning

confidence: 99%

Unnatural Phosphorus‐Containing α‐Amino Acids and Their N‐FMOC Derivatives: Synthesis and In Vitro Investigation of Anticholinesterase Activity

Dadayan,

Mkrtchyan,

Poghosyan

et al. 2024

ChemistrySelect

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Enantiomerically enriched phosphorus‐containing α‐amino acids were synthesized by the method of asymmetric synthesis, using Ni(II) square planar complex of dehydroalanine as an initial complex. After acidic hydrolysis, α‐amino acids with high enantiomeric purity were isolated. At the next stage, Fmoc derivatives of the obtained α‐amino acids were synthesized (ee >99 %). Synthesized α‐amino acids and their Fmoc derivatives exhibited anticholinesterase activity, inhibiting AChE and BuChE. At the same time, the antiacetylcholinesterase activity ranged from 14 to 77 %, and (S)‐2‐((((9H‐fluoren‐9‐yl)methoxy)carbonyl)amino)‐3‐(diisopropoxyphosphoryl) propanoic acid showed relatively high activity (77.9 %). In the case of studying the antibutyrylcholinesterase properties, the activity ranged from 4 to 71 %, and (S)‐2‐amino‐3‐(diisopropoxyphosphoryl)propanoic acid showed high activity (71 %).

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Section: The Anticholinestetrase Propertiesmentioning

confidence: 99%