SYNTHESIS AND SOME MAJOR FUNCTIONS OF VITAMIN C IN ANIMALS<sup>*</sup>

Chatterjee, I. B.; Majumder, A. K.; Nandi, B. K.; Subramanian, N.

doi:10.1111/j.1749-6632.1975.tb29266.x

Cited by 317 publications

(124 citation statements)

References 31 publications

Supporting

Mentioning

110

Contrasting

Unclassified

Order By: Relevance

“…The antioxidant activity of ascorbic acid is based on its ability to react with free radicals. Most fish species cannot synthesize ascorbic acid and have to depend on external source to meet their needs (Chatterjee et al 1975). In fish, liver and head kidney are the most significant storage organs for vitamin C (Gabaudan and Verlhac 1992).…”

Section: Discussionmentioning

confidence: 99%

Response of a freshwater air-breathing fish, Clarias batrachus to salinity stress: an experimental case for their farming in brackishwater areas in Andaman, India

et al. 2012

View full text Add to dashboard Cite

The study was conducted to assess the effects of salinity on growth and biochemical composition of freshwater catfish, Clarias batrachus. A static nonrenewable acute toxicity bioassay test was conducted and LC 50 of salinity for 96-h exposure to the fingerling (14.5 cm) was 12.52 %. Based on these results, two sublethal salinity levels, viz. 4 and 8 % were selected to study the long-term effects of salinity on C. batrachus for a period of 90 days. From the study, it was found that growth and survival rate were less in saline water (4 and 8 %). Maximum growth and survival were recorded in freshwater (0 % salinity) and subsequently at 4 and 8 %. To assess the biochemical alteration, few important biomarkers were estimated. At the end of 90 days rearing period, glucose level in the brain and blood of C. batrachus was found to decrease with salinity. The level of liver and muscle glycogen in the fish reared at 4 % was lower than that of control. Ascorbic acid in all organs under study was found to decrease with increasing salinity, which was attributed to stress mitigation effect of vitamin C. Acetylcholine esterase (AchE) activity recorded a gradual decrease with increasing salinity. Metabolic enzymes, alkaline phosphatase (ALP) activity and adenosine triphosphosphtase (ATPase) activity also reduced both in liver and muscle tissues with increasing salinity. From the present investigation, it can be concluded that exposure to higher salinity significantly (P \ 0.01) affects the growth and physiological response of Clarias batrachus.

show abstract

Section: Discussionmentioning

confidence: 99%

Response of a freshwater air-breathing fish, Clarias batrachus to salinity stress: an experimental case for their farming in brackishwater areas in Andaman, India

et al. 2012

View full text Add to dashboard Cite

show abstract

“…As modificações das concentrações de HA também em resposta à adição de ácido ascórbico em determinado sistema tem sido feita na literatura desde os trabalhos de Subramanian et alii (1973), Chaterjee (1975). No estudo conduzido por Johnston & Huang (1991) foi observado em cobaias, uma diminuição significativa de HA sérica proporcionalmente inversa às doses de suplementação de vitamina C. No presente trabalho, observamos valores menores de HA tanto no músculo esquelético quanto cardíaco, nos subgrupos suplementados, embora nem sempre tal diferença tenha sido significativa, principalmente no músculo esquelético.…”

Section: Discussionunclassified

“…A HA quando adicionada a um sistema contendo ascorbato pode ser totalmente catabolizada (com a auto-oxidação do ácido ascórbico em ácido de-hidroascórbico) em ácido aspártico, tendo como intermediários o ácido acético 2,4 diidroxi-imidazole e do ácido hidantoína-5-acético (Chaterjee, Majunder, Nandi & Subramanian, 1975), através do rompimento de sua porção imidazole (Subramanian et alii, 1973).…”

unclassified

Interaction between physical exercise and ascorbic acid supplementation on the histamine tissue of skeletal and cardiac muscles of sedentary and trained guinea-pigs

Gallani¹,

Azevedo²,

Barros³

et al. 1997

Rev. paul. educ. fís.

View full text Add to dashboard Cite

RESUMOO presente estudo objetivou avaliar em cobaias ("Cavia porcellus"), fêmeas, com três meses de idade, sedentárias (SED) e treinadas (TRE = natação, 30 min/dia, durante sete semanas) o comportamento da concentração tecidual de histamina muscular e cardíaca, em resposta ao exercício agudo (E = exercício agudo -natação, 30 minutos, R = repouso) e à suplementação de ácido ascórbico (SU = suplementados -35 mg/kg de peso, NS = não suplementados). Foram constatadas as seguintes diferenças significativas (p < 0,05): a) no grupo sedentário, aumento da histamina muscular e cardíaca tanto nos subgrupos não suplementados como nos suplementados, o mesmo ocorrendo entre os animais treinados-exercitados agudamente somente naqueles suplementados; b) menor aumento de histamina muscular nos animais treinados -não suplementados -exercitados agudamente quando comparados a seus respectivos controles e de histamina cardíaca nos animais sedentários -suplementados -exercitados agudamente, quando comparados aos não suplementados, na mesma condição, e c) diminuição da histamina cardíaca nos animais sedentários, em repouso e suplementados.

show abstract

“…Ascorbate contributes to many important enzyme reactions, including those leading to the synthesis of norepinephrine, carnitine, cholesterol, amino acids, and several peptide hormones (Chatterjee et al, 1975). In many of these processes, ascorbate serves as a co-factor and electron donor in reactions catalyzed by dioxygenase enzymes (Arrigoni & De Tullio, 2002).…”

Section: Ascorbate Dietary Requirements and Functionmentioning

confidence: 99%

Inflammation in the vascular bed: Importance of vitamin C

Aguirre

May

2008

Pharmacology & Therapeutics

108

View full text Add to dashboard Cite

Despite decreases in atherosclerotic coronary vascular disease over the last several decades, atherosclerosis remains a major cause of mortality in developed nations. One possible contributor to this residual risk is oxidant stress, which is generated by the inflammatory response of atherosclerosis. Although there is a wealth of in vitro, cellular, and animal data supporting a protective role for antioxidant vitamins and nutrients in the atherosclerotic process, the best clinical trials have been negative. This may be due to the fact that antioxidant therapies are applied "too little and too late." This review considers the role of vitamin C, or ascorbic acid in preventing the earliest inflammatory changes in atherosclerosis. It focuses on the three major vascular cell types involved in atherosclerosis: endothelial cells, vascular smooth muscle cells, and macrophages. Ascorbate chemistry, recycling, and function are described for these cell types, with emphasis on whether and how the vitamin might affect the inflammatory process. For endothelial cells, ascorbate helps to prevent endothelial dysfunction, stimulates type IV collagen synthesis, and enhances cell proliferation. For vascular smooth muscle cells, ascorbate inhibits dedifferentiation, recruitment, and proliferation in areas of vascular damage. For macrophages, ascorbate decreases oxidant stress related to their activation, decreases uptake and degradation of oxidized LDL in some studies, and enhances several aspects of their function. Although further studies of ascorbate function in these cell types and in novel animal models are needed, available evidence generally supports a salutary role for this vitamin in ameliorating the earliest stages of atherosclerosis.

show abstract

SYNTHESIS AND SOME MAJOR FUNCTIONS OF VITAMIN C IN ANIMALS^*

Cited by 317 publications

References 31 publications

Response of a freshwater air-breathing fish, Clarias batrachus to salinity stress: an experimental case for their farming in brackishwater areas in Andaman, India

Response of a freshwater air-breathing fish, Clarias batrachus to salinity stress: an experimental case for their farming in brackishwater areas in Andaman, India

Interaction between physical exercise and ascorbic acid supplementation on the histamine tissue of skeletal and cardiac muscles of sedentary and trained guinea-pigs

Inflammation in the vascular bed: Importance of vitamin C

Contact Info

Product

Resources

About

SYNTHESIS AND SOME MAJOR FUNCTIONS OF VITAMIN C IN ANIMALS*

Cited by 317 publications

References 31 publications

Response of a freshwater air-breathing fish, Clarias batrachus to salinity stress: an experimental case for their farming in brackishwater areas in Andaman, India

Response of a freshwater air-breathing fish, Clarias batrachus to salinity stress: an experimental case for their farming in brackishwater areas in Andaman, India

Interaction between physical exercise and ascorbic acid supplementation on the histamine tissue of skeletal and cardiac muscles of sedentary and trained guinea-pigs

Inflammation in the vascular bed: Importance of vitamin C

Contact Info

Product

Resources

About

SYNTHESIS AND SOME MAJOR FUNCTIONS OF VITAMIN C IN ANIMALS^*