Synthesis and solution property of acrylamide-sulfobetaine copolymers

Abstract

A b s t r a c t S u l f o b e t a i n e 3 -[ N , N -d i m e t h y l -N -( 2 -methacryloxylethyl)ammonio]-propane sulfonate (DMAPS) was used to copolymerize with acrylamide (AM) to prepare salt-sensitive copolymers. The optimal reaction conditions, such as initiator concentration, temperature, and reaction time, to achieve the largest weight averaged molecular weight (M w ) and the lowest polydispersity index (PDI) were studied. The reactivity ratios of AM and DMAPS (r 1 , r 2 ) were calculated to be (0.45, 0.84) by the Fineman-Ross method, and (0.47, 0.91) by the Kelen-Tüdös method. The Q-e values of DMAPS were calculated to be (0.30, −0.38). DMAPS was found to be more easily to add into the copolymer than AM to form random copolymers with a slight alternating tendency. Solution rheology and molecular size of the copolymers as a function of M w were studied in 1 M NaCl solution, a near θ-solution, by rotational rheometer and light scattering methods, respectively. Undisturbed dimension of the copolymers was evaluated according to Stockmayer-Fixman relation.

The Influence of Anionic Initiator on the Selected Properties of Poly-N-Isopropyl Acrylamide Evaluated for Controlled Drug Delivery

“…The initial initiator level has a crucial influence on the number and molecular mass of synthesized nanoparticles. The application of appropriate initiation conditions enables control of the properties of obtained macromolecules [ 13 , 14 ]. Some authors directly investigated the influence of cationic initiator on the results of the synthesis of polymeric derivatives of NIPA, including the number and the size of obtained particles [ 15 , 16 ].…”

Impact of anti-biofouling surface coatings on the properties of nanomaterials and their biomedical applications

“…[108] The linear polymer employed a tertiary amine as the cationic group and phosphate as the anionic group in each repeating unit. Whereas tertiary aminesare still the most widely used cationic group, carboxylate and sulfonate emerge as anionic groups for the development of zwitterionic coating polymers such as phosphorylcholine, [109] sulfobetaine, [109a] poly(carboxybetaine) (PCB), [110] poly(sulfobetaine) (PSB), [111] poly(carboxybetaine acrylamide) (PCBAA), [112] poly(carboxybetaine methacrylate) (PCBMA), [113] poly(sulfobetaine acrylamide) (PSBAA), [114] and poly(sulfobetaine methacrylate) (PSBMA). [115]…”

Biomimetic Principles to Develop Blood Compatible Surfaces

“…Furthermore, the surface roughness can be effectively smoothed by brush grafting with additional positive effects on material biocompatibility (49). Another benefit of the polymer approach is the possibility to prepare zwitterionic copolymers with targeted properties, including high temperature tolerance (50), salt (51, 52) or pH (53) responsivity, biodegradability (54, 55) or incorporation of anchoring groups (56, 57). Polyzwitterions can thereby combine the benefits of macromolecular scaffolds and useful local monomeric zwitterionic properties to yield optimal performance (58).…”