Synthesis and Solubility of Collagen in Rats during Recovery after High‐dose Cyclophosphamide Administration

Wie, Henrik; Beck, Eva I.

doi:10.1111/j.1600-0773.1981.tb01624.x

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…Our data show that administration of cyclophosphamide causes the peak variations in 1090-1100 cm −1 (lipid/ phospholipid DNA backbone), 1280-1282 cm −1 (collagen), and 1447-1450 cm −1 (DNA/RNA protein lipid) [24]. There were previous researches showing that high dose of cyclophosphamide affects the skin especially for protein/collagen components [25,26], and our data correlate well with the previous studies.…”

Section: No Chemo Groupsupporting

confidence: 81%

Longitudinal Raman Spectroscopic Observation of Skin Biochemical Changes due to Chemotherapeutic Treatment for Breast Cancer in Small Animal Model

Seong

Myoung

Lee

et al. 2017

Journal of Spectroscopy

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The cancer field effect (CFE) has been highlighted as one of indirect indications for tissue variations that are insensitive to conventional diagnostic techniques. In this research, we had a hypothesis that chemotherapy for breast cancer would affect skin biochemical compositions that would be reflected by Raman spectral changes. We used a fiber-optic probe-based Raman spectroscopy to perform preliminary animal experiments to validate the hypothesis. Firstly, we verified the probing depth of the fiber-optic probe (~800 μm) using a simple intravenous fat emulsion-filled phantom having a silicon wafer at the bottom inside a cuvette. Then, we obtained Raman spectra during breast cancer treatment by chemotherapy from a small animal model in longitudinal manner. Our results showed that the treatment causes variations of biochemical compositions in the skin. For further validation, the Raman spectra will have to be collected from more populations and spectra will need to be compared with immunohistochemistry of the breast tissue.

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Section: No Chemo Groupsupporting

confidence: 81%

Longitudinal Raman Spectroscopic Observation of Skin Biochemical Changes due to Chemotherapeutic Treatment for Breast Cancer in Small Animal Model

Seong

Myoung

Lee

et al. 2017

Journal of Spectroscopy

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“…The synthesis of collagen has also been impaired with cyclophosphamide in rats [74], which may lead to increased bone fragility in the same way as seen with osteogenesis imperfects [75]. Whether similar effects would occur in the adult skeleton is unknown.…”

Section: Cyclophosphamidementioning

confidence: 94%

Adverse Effects of Drugs on Bone and Calcium Metabolism/Physiology

Vestergaard

2007

Clinic Rev Bone Miner Metab

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Drugs may affect bone turnover and density in many ways. However, the disease for which the drugs are administered may also contribute to bone loss. Infection with human immunodeficiency virus leads to a loss of bone mineral, while treatment with highly active antiretroviral therapy does not seem to contribute to further bone loss. Type 1 diabetes is associated with a decrease in bone mineral, while type 2 diabetes is associated with an increase. The new class of thiazolidinediones (glitazones) has been associated with an increased loss of bone mineral. In breast cancer treatment, tamoxifen is associated with an increased bone mineral, while the newer class of aromatase inhibitors through a decrease in serum oestradiol are associated with an increased loss of bone mineral. Strong analgesics (opioids) may decrease bone mineral density through inhibition of gonadotrophins while weak analgesics such as the non-steroidal anti-inflammatory drugs may increase bone mineral through an effect on the prostaglandin system. However, possibly through an increased risk of falls, the weak analgesics are associated with an increased risk of fractures. Proton pump inhibitors may lead to a decreased calcium absorption and thus a decreased bone mineral and an increased risk of fractures.

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Drugs Acting on Dermal Connective Tissue

Nusgens¹,

Lapière²

1989

Pharmacology of the Skin II

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Synthesis and Solubility of Collagen in Rats during Recovery after High‐dose Cyclophosphamide Administration

Cited by 4 publications

References 14 publications

Longitudinal Raman Spectroscopic Observation of Skin Biochemical Changes due to Chemotherapeutic Treatment for Breast Cancer in Small Animal Model

Longitudinal Raman Spectroscopic Observation of Skin Biochemical Changes due to Chemotherapeutic Treatment for Breast Cancer in Small Animal Model

Adverse Effects of Drugs on Bone and Calcium Metabolism/Physiology

Drugs Acting on Dermal Connective Tissue

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