Synthesis and self-assembly of amphiphilic hyperbranched polyglycerols modified with palmitoyl chloride

Cheng, Haixing; Wang, Siguang; Yang, Jianwu; Zhou, Yongfeng; Yan, Deyue

doi:10.1016/j.jcis.2009.05.026

Cited by 47 publications

(37 citation statements)

References 41 publications

(47 reference statements)

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“…[ 41 , 42 ] Very recently, we have observed that the HPG modifi ed with palmitoyl chloride can self-assemble into large micelles over 100 nm in water. [ 43 ] As mentioned above, many amphiphilic HBPs tend to selfassemble into big micelles around 100 nm or more. Since the amphiphilic HBPs have a small hydrodynamic volume around 10 nm, [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] what is the self-assembly mechanism for such big micelles?…”

Section: Self-assembly Of 0d Micellesmentioning

confidence: 94%

Self‐Assembly of Hyperbranched Polymers and Its Biomedical Applications

et al. 2010

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Hyperbranched polymers (HBPs) are highly branched macromolecules with a three-dimensional dendritic architecture. Due to their unique topological structure and interesting physical/chemical properties, HBPs have attracted wide attention from both academia and industry. In this paper, the recent developments in HBP self-assembly and their biomedical applications have been comprehensively reviewed. Many delicate supramolecular structures from zero-dimension (0D) to three-dimension (3D), such as micelles, fibers, tubes, vesicles, membranes, large compound vesicles and physical gels, have been prepared through the solution or interfacial self-assembly of amphiphilic HBPs. In addition, these supramolecular structures have shown promising applications in the biomedical areas including drug delivery, protein purification/detection/delivery, gene transfection, antibacterial/antifouling materials and cytomimetic chemistry. Such developments promote the interdiscipline researches among surpramolecular chemistry, biomedical chemistry, nano-technology and functional materials.

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Section: Self-assembly Of 0d Micellesmentioning

confidence: 94%

Self‐Assembly of Hyperbranched Polymers and Its Biomedical Applications

et al. 2010

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“…[178] The group showed that, depending on the solvent, it is possible to control the unimolecular character of the amphiphilic PG architectures by varying the content of the hydrophobic shell. Core/shell architectures with a relatively high alkyl grafting ratio can form unimolecular micelles in THF and assemble into giant vesicles around 1-10 mm in THF/water mixed solvents.…”

Section: Non-aqueous Encapsulation Systemsmentioning

confidence: 99%

Dendritic Polyglycerols for Biomedical Applications

et al. 2009

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The application of nanotechnology in medicine and pharmaceuticals is a rapidly advancing field that is quickly gaining acceptance and recognition as an independent area of research called "nanomedicine". Urgent needs in this field, however, are biocompatible and bioactive materials for antifouling surfaces and nanoparticles for drug delivery. Therefore, extensive attention has been given to the design and development of new macromolecular structures. Among the various polymeric architectures, dendritic ("treelike") polymers have experienced an exponential development due to their highly branched, multifunctional, and well-defined structures. This Review describes the diverse syntheses and biomedical applications of dendritic polyglycerols (PGs). These polymers exhibit good chemical stability and inertness under biological conditions and are highly biocompatible. Oligoglycerols and their fatty acid esters are FDA-approved and are already being used in a variety of consumer applications, e.g., cosmetics and toiletries, food industries, cleaning and softening agents, pharmaceuticals, polymers and polymer additives, printing photographing materials, and electronics. Herein, we present the current status of dendritic PGs as functional dendritic architectures with particular focus on their application in nanomedicine, in drug, dye, and gene delivery, as well as in regenerative medicine in the form of non-fouling surfaces and matrix materials.

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“…Conjugation of hydrophobic molecules to the terminal groups changes the arms' hydrophobicity and large multimolecular aggregates (MMA) with different shapes can be formed. Formation of large aggregates at a critical aggregate concentration CAC has been reported for HPG in which the terminal hydroxyl groups have been modified by long alkyl chains [20], adamantyl group [21], or amphiphilic chains forming core-multishell structures [19,22,23]. Despite in many applications the encapsulation ability of MMA is a determinant factor; to the best of our knowledge the thermodynamic parameters that control this process have not been studied.…”

Section: Introductionmentioning

confidence: 94%