Synthesis and self-assembly behavior of novel polyaspartamide derivatives for anti-tumor drug delivery

Moon, Jong Rok; Kim, Min Woong; Kim, Dukjoon; Jeong, Ji Hoon; Kim, Ji‐Heung

doi:10.1007/s00396-010-2307-6

Cited by 30 publications

(16 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The latter can be easily prepared by thermal polycondensation of aspartic acid . By using different ring opening reagents, various functional groups can be easily introduced into the side chain of PAsp . Hence, PAsp would be a good candidate for preparing polypeptide derivatives.…”

Section: Introductionmentioning

confidence: 99%

“…27 By using different ring opening reagents, various functional groups can be easily introduced into the side chain of PAsp. [28][29][30][31][32] Hence, PAsp would be a good candidate for preparing polypeptide derivatives. The first PAsp-based hydrogel was prepared by Nagatomo, by using diamine to partially cross-link the polysuccinimide, and subsequently hydrolyzing the remaining imide ring with an alkali.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An injectable and biodegradable hydrogel based on poly(α,β‐aspartic acid) derivatives for localized drug delivery

Wang

et al. 2013

J Biomedical Materials Res

View full text Add to dashboard Cite

An injectable hydrogel via hydrazone cross-linking was prepared under mild conditions without addition of cross-linker or catalyst. Hydrazine and aldehyde modified poly(aspartic acid)s were used as two gel precursors. Both of them are water-soluble and biodegradable polymers with a protein-like structure, and obtained by aminolysis reaction of polysuccinimide. The latter can be prepared by thermal polycondensation of aspartic acid. Hydrogels were prepared in PBS solution and characterized by different methods including gel content and swelling, Fourier transformed-infrared spectroscopy, and in vitro degradation experiment. A scanning electron microscope viewed the interior morphology of the obtained hydrogels, which showed porous three-dimensional structures. Different porous sizes were present, which could be well controlled by the degree of aldehyde substitution in precursor poly(aspartic acid) derivatives. The doxorubicin-loaded hydrogels were prepared and showed a pH-sensitive release profile. The release rate can be accelerated by decreasing the environmental pH from a physiological to a weak acidic condition. Moreover, the cell adhesion and growth behaviors on the hydrogel were studied and the polymeric hydrogel showed good biocompatibility.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An injectable and biodegradable hydrogel based on poly(α,β‐aspartic acid) derivatives for localized drug delivery

Wang

et al. 2013

J Biomedical Materials Res

View full text Add to dashboard Cite

show abstract

“…Polyaspartamides, PolyAspAms, include a wide range of PASP amide derivatives that can be prepared using either an aminolysis reaction with PSI or a secondary reaction of carboxylic pendant groups of PASP. The various aminolysis reactions can then convert PSI into more useful functional polymers or cross-linked gel materials [30,31].…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of CO2-responsive poly(amino acid) derivatives with guanidine group

et al. 2015

Self Cite

View full text Add to dashboard Cite

Polyaspartamides, which are termed to a variety of amide derivatives of poly(aspartic acid), one of the poly(amino acid)s or polypeptides, have been intensively investigated as biodegradable and biocompatible polymers with a broad range of potential biomedical applications as well as eco-friendly industrial uses. By discovering that polymers containing amidine or guanidine functionality have been shown to be reversibly responsive to carbon dioxide (CO 2 ), we have developed two polyaspartamide systems: novel CO 2 -responsive hydrogel and amphiphilic polyaspartamide derivative containing L-arginine. In this work, poly(2-hydroxyethyl aspartamide) derivative was modified with L-arginine unit (PHEA-Larg), before cross-linked by hexamethylene diisocyanate in the presence of dibutyltin dilaurate catalyst to provide a hydrogel having not only good gel strength, but reversible CO 2 absorption characteristics. On the other hand, amphiphilic polyaspartamide derivative containing hydrophobic long alkyl moiety (octyl) and L-arginine unit was synthesized, and the CO 2 -responsive solubility and molecular self-assembly behaviors of the systems were investigated. These new polyaspartamide systems have potential in several applications including CO 2 capture, CO 2 -responsive and switchable surface, sensor, smart hydrogel for controlled drug delivery system, etc.

show abstract

“…[26][27][28][29][30][31][32] These polymers have physicochemical characteristics suitable for the development of biomaterials in drug delivery systems in the forms of polymer prodrugs, hydrogels, or nanomaterials. [33][34][35][36][37][38] A hybrid hydrogel based on polyaspartamide and alginate is interesting as a novel biodegradable and environment-friendly adsorbent material. Alginate (Alg) is one of naturally abundant and cheap polysaccharide.…”

Section: Introductionmentioning

confidence: 99%

Metal-ion Adsorption by Hybrid Gel based on Polyaspartamide and Alginate

Bui¹,

Jeon²,

Kim³

et al. 2016

Self Cite

View full text Add to dashboard Cite

A hydrogel based on poly(2-hydroxyethyl aspartamide) (PHEA) and alginate (Alg) derivatives, prepared by the 'click' reaction, has been utilized as a sorbent for the removal of metal-ions from aqueous media. PHEA/Alg hybrid gel exhibited high adsorption capacity for Cu(II) and Ni(II) with 75 and 60 mg/g, respectively. The hybrid gel possessed swelling degrees in the range of 60~80 g/g in ion-containing (2 wt/v%) water. The effects of pH, initial metal-ion concentration, temperature, and contact time, on the adsorption were investigated. The gel morphology and interaction between polymer and metal-ion were characterized by using SEM and FTIR spectroscopy. The kinetics and adsorption isotherms were better fitted to Langmuir model than Freundlich model, and pseudo-second-order adsorption kinetics described well the adsorption process.

show abstract

Synthesis and self-assembly behavior of novel polyaspartamide derivatives for anti-tumor drug delivery

Cited by 30 publications

References 34 publications

An injectable and biodegradable hydrogel based on poly(α,β‐aspartic acid) derivatives for localized drug delivery

An injectable and biodegradable hydrogel based on poly(α,β‐aspartic acid) derivatives for localized drug delivery

Preparation and characterization of CO2-responsive poly(amino acid) derivatives with guanidine group

Metal-ion Adsorption by Hybrid Gel based on Polyaspartamide and Alginate

Contact Info

Product

Resources

About