Synthesis and Self-assembly Behavior of a Thermo-/photo-dual Responsive Triblock Copolymer

Pan, Gaoxiang; Feng, Ze; Wei, Jia; Yan-lei, YU

doi:10.6023/a13010117

Cited by 3 publications

(2 citation statements)

References 7 publications

(7 reference statements)

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“…Therefore, our objective is to identify a coupling agent that can enhance both the distribution of HAP within the PLLA matrix and its interaction with PLLA. Epoxized soybean oil (ESBO) is derived from soybean oil and is known for its non-toxicity, metabolization, accessibility, and cost-effectiveness [ 14 ]. This oil can be applied to biological materials [ 15 ] and can be used as an effective plasticizer [ 16 ] for PLLA which may alter its processability.…”

Section: Introductionmentioning

confidence: 99%

Epoxidized Soybean Oleic Acid/Oligomeric Poly(lactic acid)-Grafted Nano-Hydroxyapatite and Its Role as a Filler in Poly(L-lactide) for Potential Bone Fixation Application

Huang,

Luo,

Chao

et al. 2024

Materials

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One of the most effective strategies for modifying the surface properties of nano-fillers and enhancing their composite characteristics is through polymer grafting. In this study, a coprecipitation method was employed to modify hydroxyapatite (HAP) with epoxidized soybean oleic acid (ESOA), resulting in ESOA-HAP. Subsequently, oligomeric poly(lactic acid) (OPLA) was grafted onto the surface of ESOA-HAP, yielding OPLA-ESOA-HAP. HAP, ESOA-HAP, and OPLA-ESOA-HAP were comprehensively characterized. The results demonstrate the progressive grafting of ESOA and OPLA onto the surface of HAP, resulting in enhanced hydrophobicity and improved dispersity in organic solvent for OPLA-ESOA-HAP compared to HAP. The vitality and adhesion of Wistar rat mesenchymal stem cells (MSCs) were assessed using HAP and modified HAP materials. Following culture with MSCs for 72 h, the OPLA-ESOA-HAP showed an inhibition rate lower than 23.0% at a relatively high concentration (1.0 mg/mL), which is three times lower compared to HAP under similar condition. The cell number for OPLA-ESOA-HAP was 4.5 times higher compared to HAP, indicating its superior biocompatibility. Furthermore, the mechanical properties of the OPLA-ESOA-HAP/PLLA composite almost remained unaltered ever after undergoing two stages of thermal processing involving melt extrusion and inject molding. The increase in the biocompatibility and relatively high mechanical properties render OPLA-ESOA-HAP/PLLA a potential material for the biodegradable fixation system.

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Section: Introductionmentioning

confidence: 99%

Epoxidized Soybean Oleic Acid/Oligomeric Poly(lactic acid)-Grafted Nano-Hydroxyapatite and Its Role as a Filler in Poly(L-lactide) for Potential Bone Fixation Application

Huang,

Luo,

Chao

et al. 2024

Materials

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“…Thus, SRPs showed great potential in the fields of catalysis, [8,9] chemical separation, [10,11] drug delivery [12] and sensor. [13][14][15] Combination of SRPs and other nanomaterials together could produce new composites, which could not only maintain the characteristics of nanomaterials, but also possess stimuli-responsibility.…”

Section: Introductionmentioning

confidence: 99%

Thermal and pH Dual Responsive Copolymer and Silver Nanoparticle Composite for Catalytic Application

et al. 2014

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and vinyl imidazole copolymer, P(NIPAM-co-VI), was synthesized by free radical emulsion polymerization. Then, the copolymer and silver nanoparticle composite, P(NIPAM-co-VI)-Ag, was prepared by in situ reduction of AgNO 3 with NaBH 4 . Due to the coexistence of thermal-responsive PNIPAM and pH-responsive PVI, P(NIPAM-co-VI) and P(NIPAM-co-VI)-Ag exhibited both thermal and pH responsibility, their size would change while altering the temperature or pH of the circumvent. Their thermal and pH dual responsive properties were studied by dynamic light scattering (DLS). P(NIPAM-co-VI)-Ag could be stably dispersed in water at a pH range from 3.0 to 9.3, which is favorable to use P(NIPAM-co-VI)-Ag as a catalyst in the reduction reaction of p-nitrophenol. The reaction rate constant (k app ) increased with the decrease of pH or the increase of VI content in the copolymer. Figure 1FT-IR spectra of P(NIPAM-co-VI)-1 and P(NIPAMco-VI)-1-Ag.

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Synthesis of PAA‐g‐PNVCL Graft Copolymer and Studies on Its Loading of Ornidazole

Qian

et al. 2014

Chin. J. Chem.

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A well-defined amphiphilic graft copolymer, consisting of hydrophobic poly(tert-butyl acrylate) (PtBA) backbone and hydrophilic poly(N-vinylcaprolactam) (PNVCL) side chains, was synthesized by successive reversible addition-fragmentation chain transfer (RAFT) polymerization and atom transfer radical polymerization (ATRP). A new acrylate monomer bearing a chlorine-based initiating group, tert-butyl 2-((2-chloropropanoyloxy)methyl)acrylate, was first RAFT homopolymerized in a controlled way to give a well-defined homopolymer with a narrow molecular weight distribution (M w /M n ＝1.15). This homopolymer directly initiated ATRP of N-vinylcaprolactam (NVCL) to afford a well-defined PtBA-g-PNVCL graft copolymer (M w /M n ＝1.22) via the grafting-from strategy without polymeric functionality transformation. PAA-g-PNVCL graft copolymer was prepared by selectively hydrolyzing PtBA-g-PNVCL. Ornidazole (ONZ)-loaded polymeric micelles using PAA-g-PNVCL copolymer as carrier were prepared by physical entrapping. Drug release experiment of the nano-carrier indicated the pH-dependent drug release characteristics.

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Synthesis and Self-assembly Behavior of a Thermo-/photo-dual Responsive Triblock Copolymer

Cited by 3 publications

References 7 publications

Epoxidized Soybean Oleic Acid/Oligomeric Poly(lactic acid)-Grafted Nano-Hydroxyapatite and Its Role as a Filler in Poly(L-lactide) for Potential Bone Fixation Application

Epoxidized Soybean Oleic Acid/Oligomeric Poly(lactic acid)-Grafted Nano-Hydroxyapatite and Its Role as a Filler in Poly(L-lactide) for Potential Bone Fixation Application

Thermal and pH Dual Responsive Copolymer and Silver Nanoparticle Composite for Catalytic Application

Synthesis of PAA‐g‐PNVCL Graft Copolymer and Studies on Its Loading of Ornidazole

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