Synthesis and self‐assembling behaviors of biotinylated pluronic/poly(lactic acid) biocompatible block copolymers in aqueous solutions

Li, Zi Ling; Xiong, Xiang‐Yuan; Li, Yu Ping; Gong, Yan; Gui, Xing Xing; Ouyang, Xiaoying; Lin, Hua; Zhu, Lu; Xie, Ji Lei

doi:10.1002/app.31125

Cited by 12 publications

(4 citation statements)

References 132 publications

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“…These findings confirmed that FA‐PEO‐PLA was successfully synthesised. The polymerisation degree ( n ) of PLA in FA‐PEO‐PLA was calculated according to our previous study [14, 15]. The

\overset{false¯}{normalM}

n of FA‐PEO‐PLA was calculated to be 5898.4 from the 1 H NMR spectrum.…”

Section: Resultsmentioning

confidence: 99%

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Synthesis, characterisation and in vitro release of paclitaxel‐loaded polymeric micelles

Huang

Xiong

et al. 2017

Micro & Nano Letters

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A novel folic acid (FA) poly (ethylene oxide) (PEO)/poly (lactic acid) (PLA) block copolymer conjugate (FA-PEO-PLA) was successfully synthesised by a two-step reaction. FA-PEO-PLA can form mixed micelles with low critical micelle concentration (3.2 × 10 −3 wt%). The physical properties and the structure of micelles were characterised by size distribution and transmission electron microscopy. The micelles exhibited uniform spherical structure and the average diameter was 107.9 nm with narrow size distribution (polydispersity index 0.214). Paclitaxel was loaded in micelles and the encapsulation efficiency of paclitaxel was 43%. The in vitro release of paclitaxel from micelles was initially fast in the first 8 h followed by sustained release. The Weibull model was the most appropriate mechanism for describing the release procedure. These results indicated that the FA-PEO-PLA can be used as a carrier for hydrophobic anticancer drugs.

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“…These findings confirmed that FA‐PEO‐PLA was successfully synthesised. The polymerisation degree ( n ) of PLA in FA‐PEO‐PLA was calculated according to our previous study [14, 15]. The

\overset{false¯}{normalM}

n of FA‐PEO‐PLA was calculated to be 5898.4 from the 1 H NMR spectrum.…”

Section: Resultsmentioning

confidence: 99%

“…2.3. Synthesis of FA-PEO-PLA block copolymers: FA-PEO-PLA was synthesised by bulk polymerisation according to our previous study [14,15]. The reaction took place in an oxygen-free environment without water.…”

Section: Synthesis Of Fa-peo-ohmentioning

confidence: 99%

Synthesis, characterisation and in vitro release of paclitaxel‐loaded polymeric micelles

Huang

Xiong

et al. 2017

Micro & Nano Letters

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“…Two different approaches were applied in order to immobilize pluronic micelles on the glass surface. Both included biotin-avidin conjugation, so the first step was a biotinylation of pluronic F-127, which was done according to the procedure described in the literature [18]. The following steps were taken to prepare the cells:…”

Section: Methodsmentioning

confidence: 99%

Enhancing fluorescence by using pluronic block copolymers as carriers of monomeric porphycenes

Masiera¹,

Buczyńska²,

Orzanowska³

et al. 2014

Methods Appl. Fluoresc.

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Porphycenes, structural isomers of porphyrins, usually exhibit strong fluorescence in organic solvents. However, in water they are practically insoluble or form only weakly emitting aggregates. We show that embedding porphycenes inside pluronic micelles in water solutions leads to the recovery of strong monomeric fluorescence, of which the decay times and quantum yields are similar to those observed for homogeneous solvents. One of the investigated porphycenes serves as a fluorescence sensor of the microenvironment viscosity, revealing that the viscosity inside pluronic micelles is quite high. Using confocal fluorescence microscopy, we obtained images of single pluronic micelles containing monomeric porphycene chromophores.

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“…Thus, long-term use of nondegradable polymers (such as PVP, with M w above the renal clearance limit) is problematic due to the risk of lysosomal accumulation . On the other hand, ABA triblock copolymers, commercially available as pluronic, have been employed as drug-delivery systems to replace the use of PVP. − Comprised of poly(ethylene oxide) (EO) and poly(propylene oxide) (PO) blocks, pluronics self-assemble in core–shell micelles above the critical micelle concentration (cmc) and in aqueous medium. , They exhibit outstanding properties, such as biocompatibility, sensitization of MDR cancer cells, enhancement of drug transport across cellular barriers, easy functionalization for bioconjugation purposes, high drug-loading capacity, and relative physical stability. − In recent years, our research group has used copolymeric micelles as efficient drug-delivery systems for hydrophobic PS. To our knowledge, we proposed the first study involving Pluronic P123 for targeted delivery of HYP for colorectal cancer and antimicrobial photodynamic therapies .…”

Section: Introductionmentioning

confidence: 99%

Hypericin Delivery System Based on P84 Copolymeric Micelles Linked with N-(3-Aminopropyl)-2-pyrrolidone for Melanoma-Targeted Photodynamic Therapy

Gonçalves

Braga

Oliveira

et al. 2020

ACS Appl. Polym. Mater.

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A hypericin (HYP) delivery system was developed on the basis of P84 copolymeric micelles linked covalently with N-(3-aminopropyl)-2-pyrrolidone (APP). The higher monomeric amounts of HYP when loaded in different proportions of P84 and P84-APP micelles were predicted by using a chemometric experimental design. Dynamic light scattering (DLS), ζ potential, loading efficiency, and transmission electron microscopy (TEM) were performed for characterizations of the copolymeric micelles. The particle size and low negative ζ potential showed that APP conjugation provides high levels of stability in the aqueous medium of P84 micelles. 1H1H-NOESY spectroscopy and theoretical calculations were applied to provide accurate insight on the preferential interaction sites of HYP-loaded P84 and P84-APP copolymeric micelles. The findings showed that HYP molecules were preferentially located in the core of both P84 and P84-APP micellar nanostructures. Self-assembled HYP molecules (in a more stable “head-to-tail” conformation) were observed when loaded into P84 micelles. In accordance with the chemometric experimental design the optimal ratio of P84/P84-APP (1:1) showed that the most pronounced HYP phototoxicity effect against B16-F10 melanoma cells recorded survival index that reached 18% at 10.0 μmol L–1. The findings pointed out that the high phototoxicity observed is related to the capacity of APP molecules in enhancing the HYP uptake by melanoma cells.

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Synthesis and self‐assembling behaviors of biotinylated pluronic/poly(lactic acid) biocompatible block copolymers in aqueous solutions

Cited by 12 publications

References 132 publications

Synthesis, characterisation and in vitro release of paclitaxel‐loaded polymeric micelles

Synthesis, characterisation and in vitro release of paclitaxel‐loaded polymeric micelles

Enhancing fluorescence by using pluronic block copolymers as carriers of monomeric porphycenes

Hypericin Delivery System Based on P84 Copolymeric Micelles Linked with N-(3-Aminopropyl)-2-pyrrolidone for Melanoma-Targeted Photodynamic Therapy

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