Synthesis and resolution of 1-(α-pyrrolidinylbenzyl)-2-naphthol and its application in the resolution of 2,2′-dihydroxy-1,1′-binaphthyl

Redox‐Neutral α,β‐Difunctionalization of Cyclic Amines

“…Experiments designed to determine the course of the annulation reaction and proposed mechanism. [18] Scheme 3. Substrate scope for the a,b-difunctionalization/N,O-acetal formation.…”

Escitalopram oxalate: co-existence of oxalate dianions and oxalic acid molecules in the same crystal

“…Although it is not expected from a consideration of the pK a values of oxalic acid (pK a1 = 1.23 and pK a2 = 4.19; Newkome et al, 1985) the co-existence of oxalate dianions and oxalic acid molecules in the same crystal has been observed in a number of compounds, three examples being bis(pyridinium) oxalate oxalic acid (Newkome et al, 1985), barium oxalate oxalic acid dihydrate (Chaix-Pluchery et al, 1989) and 1-(-pyrrolidiniobenzyl)-2-naphthol oxalate oxalic acid (Periasamy et al, 2004). These three compounds show the same alternating oxalate±oxalic acid hydrogen-bonded chains seen in (I).…”

Overview on the Recent Strategies for the Enantioselective Synthesis of 1, 1‐Diarylalkanes, Triarylmethanes and Related Molecules Containing the Diarylmethine Stereocenter

“…Moreover, asymmetric aminonaphthol-based supramolecular architectures are used for the chiral recognition of variousr acemic carboxylic acids and chiral NMR solvating agents for the determination of the enantiopurity of molecules. [10][11][12][13][14] There has recently been an increased interesti na ctive pharmaceutical agents and various other molecules that contain the 1, 1-diaryl stereocenter.T his has led to the development of novel synthetic strategies to access molecules havingt his structural moiety.T he currentR eview describes the varietyo f synthetic methodologies availablef or the enantioselective synthesis of 1, 1-diarylethanes, triarylmethanes and relatedm olecules with a1 ,1-diaryl stereogenic centert hat were reported since 1995. The prime focus of the Reviewi so nt he formation of the 1, 1-diarylmethine stereocenter either through the use of variouse nantioselective processes using chiral catalysts (the asymmetricc atalytic approach) or through the use of chiral substrates and achiral catalysts.…”